The Chicago White Sox (38-67) and Chicago Cubs (61-43) will face off in the MLB this afternoon. First pitch from Rate Field is scheduled for 2:10 p.m. ET. The game will broadcast live on CHSN.
The Cubs are -165 favorites to win outright on the moneyline, while the White Sox are +140 to pull off the upset. The over/under is set at 8.5 total runs.
Continue below for my Cubs vs White Sox predictions and MLB picks for Sunday, July 27, as well as probable pitchers, betting trends, injury reports and more.
My Cubs vs White Sox Prediction
- Cubs vs White Sox pick: Cubs Moneyline (-165)
My Cubs vs White Sox best bet is on the Cubs to win outright on the moneyline, with the best price currently available on DraftKings. But as always, make sure to find the best odds by checking our live MLB odds page.
Cubs vs White Sox Odds
| Cubs Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +100 | 8.5 -110o / -110u | -165 |
| White Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -120 | 8.5 -110o / -110u | +140 |
Cubs vs White Sox Preview, Picks
This system targets road favorites whose starting pitchers has a high ERA (4.56 to 53.7) and WHIP (1.36 to 10.45), suggesting below-average effectiveness, which is the situation in today's matchup between the Cubs and White Sox.
Despite their performance, these teams are still priced between -225 and -150, indicating public or market confidence not justified by pitching metrics.
The system backs these teams, capitalizing on overvalued spots where reputation overrides reality.
It focuses on regular season games from 2020–2024, isolating proven inefficiencies in recent betting markets.
Cubs vs White Sox Best Bet
- Cubs ML (-165)
