The Cincinnati Reds host the Houston Astros on May 8, 2026. First pitch from Great American Ball Park is scheduled for 6:10 p.m. ET. The game will be broadcast on SCHN.
The Reds are favored by -136 on the moneyline and by -1.5 on the run line. The Astros are +113 on the moneyline and +1.5 on the run line. The total is set at 9 runs.
Find my MLB picks and Astros vs Reds prediction below, as well as probable pitchers, weather report, and more.
Astros vs Reds Prediction
- Astros vs Reds Pick: Nick Lodolo Under 5.5 Strikeouts (-128)
My Astros vs Reds best bet is on Nick Lodolo to record Under 5.5 strikeouts today. Make sure to find the best odds by checking our live MLB odds page.
Astros vs Reds Odds
| Astros Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -175 | 9 -110o / -110u | +113 |
| Reds Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +144 | 9 -110o / -110u | -136 |
- Astros vs Reds moneyline: Astros +113, Reds -136
- Astros vs Reds over/under: 9 (-110o / -110u)
- Astros vs Reds spread: Astros +1.5 (-175), Reds -1.5 (+144)
Astros vs Reds Probable Pitchers
| RHP Mike Burrows (HOU) | Stat | LHP Nick Lodolo (CIN) |
|---|---|---|
| 1-4 | W-L | (Season debut) |
| 0.1 | fWAR (FanGraphs) | |
| 5.97 / 3.85 | ERA / xERA | |
| 5.18 / 4.27 | FIP / xFIP | |
| 13.6 | K-BB% | |
| 40.2 | GB% | |
| .373 | BABIP | |
| 94 | Stuff+ | |
| 98 | Location+ |
Astros vs Reds MLB Betting Preview
By Nick Galaida
Lefty Nick Lodolo will make his season debut for the Reds after starting the season on the injured list due to a blister issue.
During Lodolo’s rehab process in the minor leagues, he never faced more than 19 batters or threw more than 79 pitches.
He doesn’t project to be extremely limited tonight against the Astros, but he nonetheless should have some guardrails around his workload, especially with a mostly rested arm barn behind him.
Astros vs Reds Pick, Betting Analysis
Houston’s offense has dealt with some injuries of late, but it’s worth noting that they haven’t struck out more than four times against any of the last seven left-handed starters they have faced.
Lodolo doesn’t have overwhelming swing-and-miss stuff, and he’s always been less effective at home than on the road.
Pick: Nick Lodolo Under 5.5 Strikeouts (-128, DraftKings)
