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Royals vs Angels Prediction, Pick, Odds for Tuesday, September 23

Royals vs Angels Prediction, Pick, Odds for Tuesday, September 23 article feature image
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Pictured: Cole Ragans. (Credit: Denny Medley-Imagn Images)

The Los Angeles Angels host the Kansas City Royals on September 23, 2025. First pitch from Angel Stadium is scheduled for 9:38 p.m. EDT; the game will be broadcast on FDSW.

Find my MLB betting preview and Royals vs Angels prediction below, as well as probable pitchers, betting trends, injury reports and more.

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Our Royals vs Angels Prediction

  • Royals vs Angels pick: F5 Under 4.5

Our Royals vs Angels best bet is on the under total runs in the first five innings. Make sure to find the best odds by checking our live MLB odds page.


Royals vs Angels Odds

Royals Logo
Tuesday, Sep 23
9:38 p.m. ET
FDSW
Angels Logo
Royals Odds
SpreadTotalMoneyline
-1.5
+105
8.5
-115o / -105u
-155
Angels Odds
SpreadTotalMoneyline
+1.5
-125
8.5
-115o / -105u
+130
Odds via bet365. Get up-to-the-minute MLB odds here.
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Royals vs Angels Projected Starting Pitchers

LHP Cole Ragans (KCR)StatLHP Sam Aldegheri (LAA)
2-3W-L0-0
1.6fWAR (FanGraphs)-0.2
5.16/2.77ERA /xERA10.38/7.52
2.73/2.70FIP / xFIP8.45/8.29
1.26WHIP2.54
27.9%K-BB%-4.0%
37.2%GB%40.0%
109Stuff+88
100Location+82

Royals vs Angels Prediction, Betting Analysis

The Kansas City Royals (78–78) open their final road trip of the season tonight against the Los Angeles Angels (70–86). With their postseason hopes all but gone, Kansas City’s attention has shifted to finishing at .500 or better. They’ll send lefty Cole Ragans to the mound for his second start since returning from the IL, while the Angels counter with italian southpaw Sam Aldegheri.

Oddsmakers list Kansas City as a -155 favorite, with Los Angeles a +130 underdog. The full-game total is set at 8.5 runs.

Mike Trout has been a rare bright spot in a down season for the Angels, recently joining the 400-home run club. Against the Royals specifically, he’s done plenty of damage—16 homers and 40 RBIs in his career. But despite Trout’s presence, recent market movement points toward a lower-scoring environment early.

That sets up well for the “Low Total Unders with Line Movement (F5)” system from Evan Abrams. The model identifies first five innings unders in games where the full-game total ticks down between a half-run and a full run from open to close, signaling sharp money leaning under. When paired with modest wind conditions and reasonably priced juice, this system has consistently flagged early-game value in lower-scoring environments.

Pick: F5 Under 4.5 (-115, bet365)


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