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MLB Best Bets Today: Predictions & Picks for Pirates vs Guardians, Nationals vs Athletics, More for Friday, July 17

MLB Best Bets Today: Predictions & Picks for Pirates vs Guardians, Nationals vs Athletics, More for Friday, July 17 article feature image
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Jun 26, 2026; Baltimore, Maryland, USA; Baltimore Orioles first baseman Pete Alonso (25) up to bat against the Washington Nationals at Oriole Park at Camden Yards. Mandatory Credit: Lexi Thompson-Imagn Images

We have a full 15-game slate today, starting with Pirates vs Guardians at Progressive Field at 7:10 PM ET, and closing with Nationals vs Athletics at Sutter Health Park at 9:40 PM ET.

Our experts have analyzed the matchups and found great options for Friday, July 17.

Below are 4 expert MLB best bets today.


MLB Best Bets Today

The team logos in the table below represent each matchup our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.

GameTime (ET)Pick
Pittsburgh Pirates LogoCleveland Guardians Logo
7:10 PM
Baltimore Orioles LogoHouston Astros Logo
8:10 PM
Colorado Rockies LogoCincinnati Reds Logo
8:40 PM
Washington Nationals LogoOakland Athletics Logo
9:40 PM
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game.


Sean Zerillo's Pirates vs Guardians Best Bet

Pittsburgh Pirates Logo
46220
7:10 PM ET
MLB.TV
Cleveland Guardians Logo
Under 7.5 (-125 or Better)
FanDuel Logo

By Sean Zerillo

I project some value on the Under in this game.

If you want to dive deeper into this matchup, I recommend checking out BARTOLO, our new PRO baseball betting tool giving PRO subscribers access to all the data I use to project MLB games every day.

Here's a sneak peek of what BARTOLO spits out for Pirates-Guardians:

Opening Pitch: Zerillo's MLB Projections via BARTOLO Image

Pick: Under 7.5 (-125 or Better)



Tanner McGrath's Orioles vs Astros Best Bet

Baltimore Orioles Logo
46220
8:10 PM ET
MLB.TV
Houston Astros Logo
Pete Alonso Home Run (+250 or Better)
FanDuel Logo

By Tanner McGrath

Orioles slugger Pete Alonso is priced at bet365 at +300, implying a 25% chance to hit a homer tonight in Houston.

However, Action PRO projects him with 0.41 home runs, or a fair price closer to +144, which makes him a great pick.

At this time, he leads our prop edges for tonight's matchup against the Astros.

Alonso has 21 homers this season, and his splits favor him tonight. He's doing better on the road with a .262 average compared to .244 at home, and also against right-handed pitchers with an .878 OPS against .680 vs. lefties.

He's hit two dingers in his past five games, and we'll back him to get another one tonight against the Astros.

Pick: Pete Alonso Home Run (+250 or Better)



Derek Carty's Rockies vs Reds Pick

Colorado Rockies Logo
46220
8:40 PM ET
MLB.TV
Cincinnati Reds Logo
Gabriel Hughes Under 4.5 Strikeouts (-134 or Better)
FanDuel Logo

By Derek Carty

I like Gabriel Hughes under 4.5 strikeouts at -135 or better.

Hughes is not a major prospect. He never pitched deep into games in the Minor Leagues, and it’s unlikely he’ll pitch deep into this game, given he might get hit around up in the altitude at Coors Field.

Additionally, Denver's altitude significantly suppresses strikeouts.

THE BAT X projects around four strikeouts for Hughes in this start, with about a 63% chance that he stays under 4.5 strikeouts.

Pick: Gabriel Hughes Under 4.5 Strikeouts (-134 or Better)



Kev Mahserejian's Nationals vs Athletics Prediction

Washington Nationals Logo
46220
9:40 PM ET
MLB.TV
Oakland Athletics Logo
Over 10.5 (+100 or Better)
FanDuel Logo

By Kev Mahserejian

Cade Cavalli and Gage Jump are two promising young pitchers, both stuck on teams looking past 2026. Cavalli and Jump each have ERAs just below 4.00 and should be front-line starters for their respective organizations going forward.

Sadly, Sutter Health Park is a cruel mistress that may muddy these quality ERAs tonight. Jump is no stranger to the dangers of his minor league home park.

His 6.20 home ERA is well ahead of his 0.75 road ERA. Both averages are extreme in each split, but his road metrics beyond ERA are all better than home.

While Cade Cavalli has a better ERA and wOBA allowed on the road, his K% is lower, and his BB% is higher. Cavalli should come out cleaner than Jump, but his league-worst bullpen may continue hurting the team's chances.

With the Athletics offense ranking third in wRC+ at home (118 wRC+) and the Nationals offense ranking second-best against LHP (118 wRC+), there should be plenty of runs in Sacramento tonight.

Pick: Over 10.5 (+100 or Better)



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