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MLB Home Run Picks Today: Player Props for Mariners vs Orioles, Astros vs Angels, More for Wednesday, June 10

MLB Home Run Picks Today: Player Props for Mariners vs Orioles, Astros vs Angels, More for Wednesday, June 10 article feature image
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Jun 3, 2026; Anaheim, California, USA; Los Angeles Angels designated hitter Mike Trout (27) bats as Colorado Rockies catcher Hunter Goodman (15) and home plate umpire Chad Fairchild watch at Angel Stadium. Mandatory Credit: Kirby Lee-Imagn Images

It's hump day, and I've got some bangers for Wednesday night.

Read on for my 5 favorite MLB home run picks today.


MLB Home Run Picks Today

GameTime (ET)Pick
Seattle Mariners LogoBaltimore Orioles Logo
6:35 PM
Philadelphia Phillies LogoToronto Blue Jays Logo
7:07 PM
St. Louis Cardinals LogoNew York Mets Logo
7:10 PM
Chicago Cubs LogoColorado Rockies Logo
8:40 PM
Houston Astros LogoLos Angeles Angels Logo
9:38 PM
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game.


Mariners vs Orioles

Seattle Mariners Logo
46183
6:35 PM ET
MLB.TV
Baltimore Orioles Logo
Julio Rodriguez Home Run
FanDuel Logo

We don't have a huge sample size of Brandon Young in the majors, but he's been a big plus matchup for righty power (1.57 HR/9).

This ballpark is a lateral move for righty power, but the weather should be great for hitting, with temperatures in the low-80s, wind blowing out at 9 MPH, and high humidity.

J-Rod has been one of the best hitters in the league since the beginning of May, and I have the true odds here around +380, making this a great bet.

Pick: Julio Rodriguez Home Run



Phillies vs Blue Jays

Philadelphia Phillies Logo
46183
7:07 PM ET
MLB.TV
Toronto Blue Jays Logo
Bryce Harper Home Run
FanDuel Logo

At this point in his career, Max Scherzer might be the worst pitcher in the league.

He's been absolutely crushed by power this season, and even though it's only been a few games, he grades out as one of the best HR matchups in the league to both sides of the plate.

I have the true odds here around +250, making this a great bet.

Pick: Bryce Harper Home Run



Cardinals vs Mets

St. Louis Cardinals Logo
46183
7:10 PM ET
MLB.TV
New York Mets Logo
Juan Soto Home Run
FanDuel Logo

By Grant Neiffer

Soto is one of the best HR hitters in the league, and these odds are too high.

The weather in New York should be a plus for hitting, and the matchup isn't bad. Andre Pallante is a big ground-ball pitcher, but he has been worse this season and has allowed a 1.35 HR/9 to lefties.

He grades out as an average matchup for lefty power, which makes these odds too high. I have the true odds under +400, making this a great bet.

Pick: Juan Soto Home Run



Cubs vs Rockies

Chicago Cubs Logo
46183
8:40 PM ET
MLB.TV
Colorado Rockies Logo
Pete Crow-Armstrong Home Run
FanDuel Logo

Michael Lorenzen has been a gas can for lefty power this season, and these odds aren't nearly high enough.

This ballpark is a massive upgrade for power, and the weather should be great for hitting, with temperatures in the high-80s and wind crossing to right field.

I have the true odds here around +250, making this a great bet.

Pick: Pete Crow-Armstrong Home Run



Astros vs Angels

Houston Astros Logo
46183
9:38 PM ET
MLB.TV
Los Angeles Angels Logo
Mike Trout Home Run
FanDuel Logo

Peter Lambert has been good overall this season, but he's struggled with righty power.

Lambert has given up a 1.33 HR/9 to righties this season and a 1.64 HR/9 in his career.

The weather should be a plus for hitting, with wind blowing out to left field at 10 MPH and temperatures in the mid-70s.

Trout is due for some massive positive regression, as the underlying power numbers have been the best of his career.

I have the true odds here around +300, making this a great bet.

Pick: Mike Trout Home Run



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About the Author
Grant NeifferVerified Action Expert

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