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MLB Home Run Picks Today: Predictions, Props for Orioles vs Yankees, Mets vs Nationals, Astros vs A’s, More for Friday, September 25

MLB Home Run Picks Today: Predictions, Props for Orioles vs Yankees, Mets vs Nationals, Astros vs A’s, More for Friday, September 25 article feature image
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Sergio Estrada-Imagn Images. Pictured: Astros 1B Christian Walker

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For Friday's MLB slate, I'm bringing you bangers for the Orioles vs. Yankees doubleheader, plus picks for Mets vs. Nationals, Rockies vs. White Sox, and Astros vs. Athletics.

Read on for my 5 MLB Home Run Picks Today.


MLB Home Run Picks Today

In the table below, you'll find each of Grant Neiffer's top home run prop picks from today's slate of games. Click on any pick or team logo to navigate to a specific bet discussed in this article, and download the Action Network app for more picks and analysis.

GameTime (ET)Pick
Baltimore Orioles LogoNew York Yankees Logo
4:05 PM
New York Mets LogoWashington Nationals Logo
6:45 PM
Colorado Rockies LogoChicago White Sox Logo
7:40 PM
Baltimore Orioles LogoNew York Yankees Logo
8:05 PM
Houston Astros LogoOakland Athletics Logo
9:40 PM
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game.

Orioles vs Yankees Prediction, Pick

Baltimore Orioles Logo
Friday, Sept. 25
4:05 PM ET
YES
New York Yankees Logo
Christian Encarnacion-Strand Home Run
FanDuel Logo

This isn't a bad spot, and these odds are a bit too high for Christian Encarnacion-Strand.

The weather has heavy winds, but they're crossing and shouldn't affect power much.

I have the true odds for the Orioles 3B at around +450.

Pick: Christian Encarnacion-Strand Home Run



Mets vs Nationals Prediction, Pick

New York Mets Logo
Friday, Sept. 25
6:45 PM ET
MLB.TV
Washington Nationals Logo
CJ Abrams Home Run
FanDuel Logo

These odds are far too high for CJ Abrams given the spot.

We don't have a huge sample size on Mets starter Justin Hagenman in the majors, but he grades out as a big plus matchup for lefty power.

The weather should be below average for hitting, but these odds more than make up for it.

I have the true odds for the Nationals SS at around +600.

Pick: CJ Abrams Home Run



Rockies vs White Sox Prediction, Pick

Colorado Rockies Logo
Friday, Sept. 25
7:40 PM ET
MLB.TV
Chicago White Sox Logo
Munetaka Murakami Home Run
FanDuel Logo

This is an incredible spot, and these odds are far too high for Munetaka Murakami.

Rockies SP Tomoyuki Sugano might be the best matchup in the league for lefty power, as he has allowed a massive 2.29 HR/9 this season.

The weather should be below average for hitting, but I don't care when we're getting this good of a matchup at these odds.

I have the true odds for the White Sox 1B at around +350.

Pick: Munetaka Murakami Home Run



Orioles vs Yankees Prediction, Pick

Baltimore Orioles Logo
Friday, Sept. 25
8:05 PM ET
MLB.TV
New York Yankees Logo
Ben Rice Home Run
FanDuel Logo

This is a plus spot, and these odds are far too high.

Orioles starter Brandon Young has been a plus matchup for lefty power this season, allowing a 1.35 HR/9. The weather has heavy wind blowing left to right, which will have a neutral effect on lefty power (at worst).

This ballpark is one of the best in the league for lefty power, and Ben Rice is one of the best home run hitters in the league.

I have the true odds for the Yankees DH at around +400.

Pick: Ben Rice Home Run



Astros vs Athletics Prediction, Pick

Houston Astros Logo
Friday, Sept. 25
9:40 PM ET
MLB.TV
Oakland Athletics Logo
Christian Walker Home Run
FanDuel Logo

Christian Walker gets a great spot, and these odds are far too high.

Athletics SP Jacob Lopez has been a gas can for righty power this season, allowing a high 1.83 HR/9.

This ballpark is one of the best in the league for power, and the weather should be decent for hitting, with temperatures in the high-70s and wind blowing out at 5 mph.

I have the true odds for the Astros 1B at around +350.

Pick: Christian Walker Home Run



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About the Author
Grant Neiffer • Verified Action Expert

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