It's midweek already, and we have 16 games in the MLB slate for today, which gives us plenty of chances for homers.
Check out my 3 favorite MLB Home Run Picks Today for Wednesday, September 23, including picks for White Sox vs Royals and Padres vs Dodgers.
MLB Home Run Picks Today
The team logos in the table below represent each of the matchups that our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.
| Game | Time (ET) | Pick |
|---|---|---|
  | 7:40 PM | |
  | 8:05 PM | |
  | 10:10 PM | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game. | ||
White Sox vs Royals
This spot is around average, which makes these odds far too high.
Seth Lugo has been a plus matchup for righty power this season (1.23 HR/9), and he's due for some negative regression.
The weather should be slightly below average for hitting, with temps in the high-60s and wind blowing in slightly.
I have the true odds here around +450.
Pick: Miguel Vargas o0.5 Home Runs (+550)
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Mets vs Rangers
This matchup isn't great, but the books have drastically overreacted to this spot.
Nolan McLean is a matchup that is average to slightly below average for lefty power, as he has allowed a 1.15 HR/9 this season.
This ballpark isn't great for power, but Seager is one of the best HR hitters in the league.
I have the true odds here around +480.
Pick: Corey Seager 1+ Home Runs (+567)
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Padres vs Dodgers
The Dodgers righties get the best spot of any team today.
Robbie Ray is a matchup that is well above average for righty power, as he has allowed a 1.52 HR/9 while pitching in good pitcher's ballparks for most of the season.
The weather should be above average for hitting in LA, with temps in the high-70s and wind blowing out at 5 mph.
I have the true odds here around +400.
Pick: Mookie Betts o0.5 Home Runs (+450)
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