After an exciting first day, the MLB Postseason continues on Wednesday, October 1. There are another 4 Wild Card games on tap today, and our experts have found value worth betting.
Our MLB betting experts and systems have dug into today's MLB odds and made their picks and predictions below, so continue reading for today's MLB best bets.
MLB Best Bets Today
The team logos in the table below represent each of the matchups that our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.
| Game | Time (ET) | Pick |
|---|---|---|
  | 1:08 p.m. | |
  | 3:08 p.m. | |
  | 6:08 p.m. | |
  | 9:08 p.m. | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game. | ||
Sean Paul's Tigers vs Guardians Best Bet: Trust These Pitchers
By Sean Paul
In five of the past seven meetings, the Guardians and Tigers scored six or fewer combined runs. With the total sitting at 7, just like it was in Game 1, I expect a similar result. Both pitchers are very good and I don't trust either offense to put up enough runs to threaten the over. At this point, both teams want a well-pitched, low-scoring game. This game should be more of the same.
Pick: Under 7 (-125)
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Tony Sartori's Padres vs Cubs Best Bet: Runs Likely Limited
By Tony Sartori
San Diego generated only one run in Game 1, and another quiet performance is likely. The Padres finished the regular season in the bottom half of the league in slugging percentage (SLG), OPS and home runs.
While the Cubs boast a much stronger lineup, they have struggled against Dylan Cease. Through 108 combined plate appearances against him, this current Chicago roster owns a mere .194 batting average, .327 slugging percentage and a .261 weighted on-base average (wOBA).
Pick: Under 6.5 (+100)
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Bet Labs' Red Sox vs Yankees Best Bet: System Suggests Under
By Bet Labs
This system targets unders in MLB series games (Game 2 or later) where both teams have winning records, suggesting quality pitching and competitive matchups.
However, when public betting leans toward the over — as the public likely expects fireworks between top teams — it creates contrarian value on the under. By capitalizing on low public support for the under (≤35%), this strategy fades public perception in favor of market inefficiencies, especially when bettors overestimate offensive output late in a series.
Overall, this system has generated a 5% ROI and cashed at a 54% clip (1390-1183-110).
Pick: Under 7.5 (-120)
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Sean Zerillo's Reds vs Dodgers Best Bet: Back Yamamoto
By Sean Zerillo
Yoshinobu Yamamoto (2.73 xERA, 20.8% K-BB% in 2025) is the far more sophisticated pitcher, and with a home run rate (0.72 HR/9) nearly half of that of his opponent, he gives the light-hitting Reds (26th, 85 wRC+) a minimal chance of securing a lead.
I'll continue to insist that Dave Roberts is prepared to run his starting pitchers (1st xFIP and K-BB%, 2nd in Pitching+ post-deadline) until they necessitate a relief pitcher, rather than deploying pre-planned game scripts for relief usage.
As a result, Yamamoto over 17.5 outs (-110) — a number he cleared on 15 of 30 occasions this season — is potentially worth a small poke given the soft matchup.
Yamamoto only averaged 71 pitches per start last September and 70.5 pitches per start last postseason. However, the Dodgers took the leash off this year, as Yamamoto averaged 101.25 pitches per month over the past 30 days, and I expect similar usage in October.
Pick: Yoshinobu Yamamoto Over 17.5 Outs (-105)
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