The Chicago Cubs host the Boston Red Sox on July 20, 2025. First pitch from Wrigley Field is scheduled for 2:20 p.m. ET; the game will be broadcast on NESN and MLB.TV.
The Red Sox enter as -135 favorites on the moneyline, while the Cubs are +115 to pull off the upset. The over/under comes in at a low 6.5 total runs.
Find my Red Sox vs Cubs prediction and MLB betting preview below, as well as probable pitchers, betting trends, injury reports, and more.
Boston Red Sox vs Chicago Cubs Prediction, Picks
- Red Sox vs Cubs Pick: Under 6.5
My Red Sox vs Cubs best bet is the under 6.5. Make sure to find the best odds by checking our live MLB odds page.
Red Sox vs Cubs Odds, Spread, Lines
| Red Sox Odds | ||
|---|---|---|
| Run Line | Total | Moneyline |
-1.5 +135 | 6.5 -120o / +100u | -135 |
| Cubs Odds | ||
|---|---|---|
| Run Line | Total | Moneyline |
+1.5 -160 | 6.5 -120o / +100u | +115 |
Red Sox vs Cubs Projected Pitchers
| Garrett Crochet (BOS) | Stat | Cade Horton (CHC) |
|---|---|---|
| 10-4 | W-L | 3-3 |
| 4.3 | fWAR (FanGraphs) | 0.4 |
| 2.23/2.84 | ERA /xERA | 4.45/4.62 |
| 2.41/2.68 | FIP / xFIP | 4.40/4.50 |
| 1.04 | WHIP | 1.41 |
| 24.6 | K-BB% | 10.2 |
| 49.4 | GB% | 48 |
| 114 | Stuff+ | 97 |
| 98 | Location+ | 100 |
Red Sox vs Cubs Pick, Best Bets
This MLB betting system targets unders in games played at wind-sensitive stadiums—such as Wrigley Field, Fenway Park, and Oriole Park—when the wind is blowing in. These conditions significantly reduce ball carry, often leading to lower run production. Whether during the regular season or postseason, betting the under in these specific wind-in scenarios has consistently delivered strong short- and long-term profitability.
By focusing on ballparks where weather has a proven impact on suppressing offense, this strategy capitalizes on overlooked environmental edges in the MLB betting market.
Pick: Under 6.5
Moneyline
There is no play on the moneyline.
Run Line (Spread)
There is no play on the run line.
Over/Under
Take the under in Red Sox vs. Cubs today.
