Reds vs Cubs Prediction, Odds: MLB Picks, Preview for Wednesday, August 6

Reds vs Cubs Prediction, Odds: MLB Picks, Preview for Wednesday, August 6 article feature image
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Imagn Images: Michael Busch

Starting soon
Odds Updating Soon
Matchup - 8/06 6:20pm UTCSpreadTotalMoneyline
+1.5-190
o7.5+100
+115
-1.5+155
u7.5-118
-135

The Cincinnati Reds (60-54) and Chicago Cubs (65-48) will face off in the MLB this afternoon. First pitch from Wrigley Field is scheduled for 2:20 p.m. ET. The game will broadcast live on MARQ.

Chicago is a -135 favorite to win outright on the moneyline, while Cincinnati is +115 to pull off the upset. The over/under is set at 7.5 total runs.

Continue below for my Reds vs Cubs predictions and MLB picks for Wednesday, August 6, as well as probable pitchers, betting trends, injury reports and more.

Quickslip

Reds vs Cubs Prediction, Picks

  • Reds vs Cubs pick: Under 7.5 Runs (-115)

My Cubs vs. Reds best bet is on the under, with the best price currently available at Fanatics. But as always, make sure to find the best odds by checking our live MLB odds page.


Reds vs Cubs Odds for Wednesday, August 6

Reds Logo
Wednesday, August 6
2:20 p.m. ET
MARQ
Cubs Logo
Reds Odds
SpreadTotalMoneyline
+1.5
-194
7.5
-105o / -115u
+115
Cubs Odds
SpreadTotalMoneyline
-1.5
+158
7.5
-105o / -115u
-135
Odds via DraftKings. Get up-to-the-minute MLB odds here.
DraftKings Logo

Cincinnati Reds vs Chicago Cubs MLB Preview

This system capitalizes on an overlooked weather edge in MLB totals betting.

It focuses on regular-season games when elevated humidity — ranging from 45 to 95 — intersects with moderate temperatures and neutral wind patterns, which is the forecast entering today's matchup between the Reds and Cubs.

Despite assumptions that humidity boosts offense, public bettors are fading these conditions, which actually correlate with suppressed scoring in certain environments.

In these spots, the home team has stayed under in recent games, with their five-game over rate sitting below 40, suggesting low offensive rhythm.

The market has subtly corrected as well, with the total dropping from open to close, and the overall percentage of bets on the over remains modest — between 6 and 29.

These indicators combine to identify under-the-radar under spots where public narratives misalign with actual scoring trends.

MLB Icon
Evan Abrams / Bet Labs – Public Fades Humidity = Unders
the average humidity is between 45% and 95%
the home team's 5 Game over percentage is between 0% and 40%
the temperature is between 54 and 97 degrees
the wind direction is From Right or Left To Right or From Left or Right To Left or In or None
the o/u change from open to close is between -1 and 0
the over/under % is between 6% and 29%
the game was played during the 2025 or 2024 or 2023 or 2022 or 2021 or 2020 season
betting on the Under
the game is played during the Regular season
$8,077
WON
294-193-19
RECORD
60%
WIN%

Reds vs Cubs Betting Prediction

  • Under 7.5 (-115)

Reds vs Cubs Betting Trends



Reds vs Cubs Weather


Get the latest coverage on MLB Weather.

For the latest on MLB injuries, be sure to check out our MLB Injury Report page.

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