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Padres vs Dodgers Prediction, Pick, MLB Odds for Wednesday, September 23

Padres vs Dodgers Prediction, Pick, MLB Odds for Wednesday, September 23 article feature image
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Pictured: Los Angeles Dodgers shortstop Mookie Betts. (Credit: William Liang-Imagn Images)

The Los Angeles Dodgers host the San Diego Padres on September 23, 2026. First pitch from UNIQLO Field at Dodger Stadium is scheduled for 10:10 p.m. EDT. The game will be broadcast on SDPA.

The Dodgers are favored by -225 on the moneyline and by -1.5 on the run line. The Padres are +188 on the moneyline and +1.5 on the run line. The total is set at 8.5 runs.

Find my MLB picks and Padres vs Dodgers prediction below, as well as probable pitchers, weather report, and more.


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Padres vs Dodgers Prediction

  • Padres vs Dodgers Pick: Mookie Betts Home Run (+450)

My Padres vs Dodgers best bet is on Mookie Betts to hit a homer. Make sure to find the best odds by checking our live MLB odds page and download the Action Network app for more picks and analysis!


Padres vs Dodgers Odds

Padres Logo
Wednesday, Sep 23
10:10 p.m. ET
SDPA
Dodgers Logo
Padres Odds
SpreadTotalMoneyline
+1.5
-115
8.5
106o / -130u
+188
Dodgers Odds
SpreadTotalMoneyline
-1.5
-104
8.5
106o / -130u
-225
Odds via FanDuel. Get up-to-the-minute MLB odds here.
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  • Padres vs Dodgers moneyline: Padres +188, Dodgers -225
  • Padres vs Dodgers over/under: 8.5 (+106o / -130u)
  • Padres vs Dodgers spread: Dodgers -1.5 (-104), Padres +1.5 (-115)

Padres vs Dodgers Probable Pitchers

Robbie Ray (LHP, SDP)StatYoshinobu Yamamoto (RHP, LAD)
13-8W-L14-8
0.8fWAR (FanGraphs)4.6
3.60/4.79ERA / xERA2.51/2.95
4.73/4.90FIP / xFIP3.28/3.25
8.0%K-BB%20.1%
34.5%GB%48.3%
.252BABIP.217
94Stuff+102
89Location+107

Padres vs Dodgers MLB Betting Preview, Expert Pick

The Dodgers righties get the best spot of any team today.

Robbie Ray is a well above average matchup for righty power allowing a 1.5 HR/9 while pitching in good pitchers ballparks most of the season.

The weather is above average for hitting over in LA with temps in the high 70s and wind blowing out at 5 MPH.

I have the true odds on Betts around +400 today.

Pick: Mookie Betts Home Run (+450, FanDuel)


Padres vs Dodgers Weather


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About the Author
Grant NeifferVerified Action Expert

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