The Chicago Cubs host the Seattle Mariners on June 21, 2025. First pitch from Wrigley Field is scheduled for 2:20 p.m. EDT; the game will be broadcast on MARQ.
The Mariners won the first game of the series yesterday, with a 9-4 score in windy weather, and today might bring more of the same.
Read our Mariners vs Cubs prediction and MLB pick below.
My Mariners vs Cubs Prediction
- Mariners vs Cubs picks: Over 12.5 (-115, BetMGM)
My Mariners vs Cubs best bet is Over 12.5 total runs in this game. Make sure to find the best odds by checking our live MLB odds page.
Mariners vs Cubs Odds
| Mariners Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -120 | 12.5 -115o / -105u | +145 |
| Cubs Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +100 | 12.5 -115o / -105u | -175 |
Mariners vs Cubs Projected Starting Pitchers
| RHP Emerson Hancock (SEA) | Stat | RHP Cade Horton (CHC) |
|---|---|---|
| 3-2 | W-L | 3-1 |
| 0.2 | fWAR (FanGraphs) | 0.5 |
| 4.48 / 4.81 | ERA / xERA | 3.47 / 3.85 |
| 4.82 / 4.31 | FIP / xFIP | 3.73 / 3.91 |
| 1.38 | WHIP | 1.21 |
| 9.2 | K-BB% | 13.7 |
| 43.5 | GB% | 46.4 |
| 87 | Stuff+ | 97 |
| 102 | Location+ | 102 |
Mariners vs Cubs Prediction, Betting Analysis
I am very confident that this will not close at a 12-run total.
We had temperatures close to 80 degrees with two solid pitchers in George Kirby and Matthew Boyd on Friday, and the game finished with 13 total runs.
We have two young pitchers on Saturday, Mariners' Emerson Hancock and Cubs' Cade Horton, and I can guarantee that they will be frustrated by these conditions.
Wrigley Field is the most wind-sensitive park in the league. With winds projected to blow straight out at 25 MPH, a 92-degree game-time temperature, and a 100-degree heat index, we are experiencing elite hitting conditions.
I figured we would see 13.5 or 14 as a total, and I wouldn't be surprised if it moves up to that number.
I am not an "over" bettor, especially with high totals, but this is a lousy line that surely won't last.
Pick: Over 12.5 (-115, BetMGM)
