The Chicago Cubs host the St. Louis Cardinals on Friday, July 4, 2025. First pitch from Wrigley Field is scheduled for 2:20 p.m. ET; the game will be broadcast on Apple TV+.
Find my MLB betting preview for this NL Central clash and Cardinals vs Cubs prediction below, as well as probable pitchers, betting trends and more.
My Cardinals vs Cubs Prediction
- Cardinals vs Cubs picks: Cubs Moneyline (-135 to -150)
My Cardinals vs Cubs best bet is the Cubs moneyline. Make sure to find the best odds by checking our live MLB odds page.
Cardinals vs Cubs Odds
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 +137 | 9.5 -121o / -104u | +116 |
| Cubs Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 -163 | 9.5 -121o / -104u | -138 |
Cardinals vs Cubs Projected Starting Pitchers
| RHP Miles Mikolas (STL) | Stat | RHP Colin Rea (CHC) |
|---|---|---|
| 4-5 | W-L | 5-3 |
| 1.1 | fWAR (FanGraphs) | 0.3 |
| 4.76 / 4.66 | ERA /xERA | 4.37 / 5.24 |
| 3.96 / 4.68 | FIP / xFIP | 4.83 / 4.45 |
| 1.32 | WHIP | 1.37 |
| 10.3% | K-BB% | 11.1% |
| 37.7% | GB% | 36.3% |
| 88 | Stuff+ | 96 |
| 106 | Location+ | 100 |
Brit Devine’s Cardinals vs Cubs Preview, Prediction
Getting the Cubs at home with a fully healthy starting lineup against Miles Mikolas at this price seems like a mistake by the books.
Cubs starter Colin Rea isn't great either, but he is backed up by a much better offense that has outdone the Cardinals' lineup in nearly every category that matters, regardless of if you look at recent performances or the season as a whole.
After having a nice run several weeks ago, the Cardinals' offense has gone ice cold, and they are coming off of a three-game series with the Pirates in which they scored no runs.
I would play this comfortably to -150.
Pick: Cubs Moneyline (-135 to -150)
Moneyline
The Cubs moneyline is the play for this game.
Run Line (Spread)
There is no bet for either run line.
Over/Under
There is no bet on the game total.
