Cardinals vs Cubs Prediction, Pick, Odds for Friday, July 4

Cardinals vs Cubs Prediction, Pick, Odds for Friday, July 4 article feature image
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David Banks-Imagn Images. Pictured: Pete Crow-Armstrong.

The Chicago Cubs host the St. Louis Cardinals on Friday, July 4, 2025. First pitch from Wrigley Field is scheduled for 2:20 p.m. ET; the game will be broadcast on Apple TV+.

Find my MLB betting preview for this NL Central clash and Cardinals vs Cubs prediction below, as well as probable pitchers, betting trends and more.

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My Cardinals vs Cubs Prediction

  • Cardinals vs Cubs picks: Cubs Moneyline (-135 to -150)

My Cardinals vs Cubs best bet is the Cubs moneyline. Make sure to find the best odds by checking our live MLB odds page.


Cardinals vs Cubs Odds

Cardinals Logo
July 4, 2025
2:20 p.m. EDT
Apple TV+
Cubs Logo
Cardinals Odds
SpreadTotalMoneyline
+1.5
+137
9.5
-121o / -104u
+116
Cubs Odds
SpreadTotalMoneyline
-1.5
-163
9.5
-121o / -104u
-138
Odds viaĀ BetMGM. Get up-to-the-minuteĀ MLB odds here.
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Cardinals vs Cubs Projected Starting Pitchers

RHP Miles Mikolas (STL)StatRHP Colin Rea (CHC)
4-5W-L5-3
1.1fWAR (FanGraphs)0.3
4.76 / 4.66ERA /xERA4.37 / 5.24
3.96 / 4.68FIP / xFIP4.83 / 4.45
1.32WHIP1.37
10.3%K-BB%11.1%
37.7%GB%36.3%
88Stuff+96
106Location+100

Brit Devine’s Cardinals vs Cubs Preview, Prediction

Getting the Cubs at home with a fully healthy starting lineup against Miles Mikolas at this price seems like a mistake by the books.

Cubs starter Colin Rea isn't great either, but he is backed up by a much better offense that has outdone the Cardinals' lineup in nearly every category that matters, regardless of if you look at recent performances or the season as a whole.

After having a nice run several weeks ago, the Cardinals' offense has gone ice cold, and they are coming off of a three-game series with the Pirates in which they scored no runs.

I would play this comfortably to -150.

Pick: Cubs Moneyline (-135 to -150)


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Moneyline

The Cubs moneyline is the play for this game.


Run Line (Spread)

There is no bet for either run line.


Over/Under

There is no bet on the game total.


Cardinals vs Cubs Betting Trends


Cardinals vs Cubs Weather


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