The San Francisco Giants host the St. Louis Cardinals on September 7, 2026. First pitch from Oracle Park is scheduled for 8:10 p.m. ET. The game will be broadcast on NBC/Peacock.
The Giants are favored by -130 on the moneyline and by -1.5 on the run line. The Cardinals are +110 on the moneyline and +1.5 on the run line. The total is set at 7.5 runs.
Find my MLB picks and Cardinals vs Giants prediction below, as well as probable pitchers, weather report, and more.
Cardinals vs Giants Prediction
- Cardinals vs Giants Pick: Rafael Devers Home Run (+400)
My Cardinals vs Giants best bet is on Rafael Devers to hit a homer tonight. Make sure to find the best odds by checking our live MLB odds page.
Cardinals vs Giants Odds
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -190 | 7.5 -115o / -105u | +110 |
| Giants Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +160 | 7.5 -115o / -105u | -130 |
- Cardinals vs Giants moneyline: Cardinals +110, Giants -130
- Cardinals vs Giants over/under: 7.5 (-115o / -105u)
- Cardinals vs Giants spread: Cardinals +1.5 (-190), Giants -1.5 (+160)
Cardinals vs Giants Probable Pitchers
| Michael McGreevy (RHP, STL) | Stat | Logan Webb (RHP, SF) |
|---|---|---|
| 6-9 | W-L | 8-8 |
| 1.5 | fWAR (FanGraphs) | 2.8 |
| 3.97 / 5.36 | ERA / xERA | 4.21 / 4.09 |
| 4.31 / 4.26 | FIP / xFIP | 3.44 / 3.83 |
| 10.2 | K-BB% | 13.0 |
| 43.5 | GB% | 50.7 |
| .281 | BABIP | .283 |
| 81 | Stuff+ | 99 |
| 111 | Location+ | 104 |
Cardinals vs Giants MLB Betting Preview, Prediction
This spot isn't anything special, but getting these odds for Rafael Devers is just silly.
Cardinals starter Michael McGreevy has been a plus matchup for lefty power in his career, allowing a 1.40 HR/9.
This ballpark is probably the worst in the league for power, but Devers has been the hottest hitter in baseball recently.
I have the true odds for the Giants DH under +400, making this a great bet.
Pick: Rafael Devers Home Run (+400, bet365)
