Bills vs. Texans Odds & Betting Predictions - November 21, 2025
Bills at Texans
1:15 am • Amazon Prime VideoBills at Texans Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
 Bills 7-3 | -3.5 | -6-110 | o43.5-115 | -270 |
 Texans 5-5 | u46.5 | +6-110 | u43.5-105 | +225 |
NRG StadiumHouston
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Bills vs. Texans Expert Picks
Cam Is Money
Last 30d: 112-105-2 (+3.5u)
J.Higgins o27.5 Rec Yds-118
1u
Will Brinson
Last 30d: 20-24-2 (-2.2u)
J.Allen Anytime TD Scorer Yes-112
1.12u
Great price here. NINE rushing tds from Week 10-Week 16 last year and he’s going to start pouring it on again as the Bills push for the AFC East.
FTN Fantasy
Last 30d: 110-126-1 (-24.5u)
HOU +3.5-110
1u
Bills vs. Texans Previews & Analysis
Bills vs. Texans Props
Prop Projections
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Prop Odds Comparison
Line Movement Tracker
Bills vs. Texans Public Betting Percentages
Betting Trends
- Texans are 2-3 in their last 5 games.
- Texans are 1-4 in their last 5 games against the spread
- Texans are 1-4 in their road games against the spread
- The totals have gone OVER in 0 of Texans' last 5 games
- The totals have gone OVER in 1 of Texans' 5 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Texans vs. Bills Injury Updates
Texans Injuries
- Joe MixonRB
Mixon is out with knee
Out
- Harrison BryantTE
Bryant is out with neck
Out
- C.J. StroudQB
Stroud is out with concussion
Out
- Tank DellWR
Dell is out with knee
Out
Bills Injuries
- Mitch WishnowskyP
Wishnowsky is out with back
Out
- Tyler BassK
Bass is out with hip
Out
- Dalton KincaidTE
Kincaid is out with hamstring
Out
Player Stats
- passing yards
C.J. Stroud1702pyds - passing touchdownsC.J. Stroud11ptd
- rushing yards
Nick Chubb419ryds - rushing touchdownsNick Chubb2rtd
Depth Charts
| Starter | 2ND | 3RD | 4TH | |||
|---|---|---|---|---|---|---|
| QB | C.J. Stroud | Davis Mills | Graham Mertz | |||
| RB | Joe Mixon | Nick Chubb | Dameon Pierce | Dare Ogunbowale | Woody Marks | Jawhar Jordan |
| WR | Christian Kirk | Jaylin Noel | Braxton Berrios | |||
| TE | Dalton Schultz | Cade Stover | Harrison Bryant | Luke Lachey | ||
| LT | Aireontae Ersery | |||||
| LG | Laken Tomlinson | |||||
| C | Jake Andrews | Jarrett Patterson | Eli Cox | |||
| RG | Ed Ingram | Juice Scruggs | ||||
| RT | Tytus Howard | Blake Fisher | Trent Brown | |||
| LDE | Will Anderson | Darrell Taylor | Derek Barnett | |||
| RDE | Danielle Hunter | Denico Autry | Dylan Horton | Solomon Byrd | ||
| WLB | Henry To'oTo'o | Christian Harris | Jake Hansen | Jackson Woodard | ||
| MLB | Azeez Al-Shaair | E.J. Speed | Jamal Hill | |||
| LCB | Derek Stingley | Jaylin Smith | Tremon Smith | |||
| SS | M.J. Stewart | Jaylen Reed | Jalen Mills | |||
| FS | Calen Bullock | Jimmie Ward | ||||
| RCB | Kamari Lassiter | |||||
| P | Tommy Townsend | |||||
| H | Tommy Townsend | |||||
| PR | Braxton Berrios | Jaylin Noel | Christian Kirk | Jawhar Jordan | ||
| KR | Dameon Pierce | Braxton Berrios | Woody Marks | Jaylin Noel | ||
| LS | Austin Brinkman | |||||
| RWR | Jayden Higgins | Tank Dell | Justin Watson | |||
| DT | Tim Settle | Folorunso Fatukasi | Kurt Hinish | Junior Tafuna | ||
| FB | Jakob Johnson | British Brooks | ||||
| NB | Jalen Pitre | Myles Bryant | Alijah Huzzie | |||
| NT | Sheldon Rankins | Mario Edwards | Tommy Togiai | Haggai Ndubuisi | ||
| LWR | Nico Collins | Xavier Hutchinson | Quintez Cephus | |||
| K | Ka'imi Fairbairn |
Team Stats
2398
YDS
2220
207/299
Comps/Atts
233/362
8.395
YPA
6.707
18/7
TDs/INTs
14/6
20/112
Sacks/Yards
25/208
24/36 66.67%
Redzone
13/30 43.33%
53/118 0%
3rd Down
49/136 0%
5/10 0%
4th Down
10/16 0%
Bills vs. Texans Odds Comparison
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Bills at Texans Team Totals
MatchupOverUnder | ||
|---|---|---|
Bills 7-3 | N/A | N/A |
Texans 5-5 | N/A | N/A |