Packers vs. Browns Odds & Betting Predictions - September 21, 2025

Packers at Browns

5:00 pm • FOX

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Green Bay Packers

2-0

Cleveland Browns

0-2

MatchupOpenSpreadTotalMoneyline
Packers 2-0	-6.5	-8-110	o41.5-110	-430
Browns 0-2	u43.5	+8-110	u41.5-110	+332

Sunday 5:00 p.m.

September 21, 2025

Huntington Bank FieldCleveland

78°Fahrenheit

0%Rain

9Wind

CLE +8.5-108

0.6u

CLE +390

0.25u

CLE +8.5-110

1.1u

Outright. Reeks of the Browns/Niners game from 2 years ago. Browns honestly 2 decent datapoints despite being 0-2 and losing bad last week scoreboard wise. Think anything above 7 at home is too many

CLE +9.5-129

@braydenhenry

CLE +9-110

Under 42.5-110

1.8u

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NFL Public Betting

Browns are 0-2 in their last 5 games.
Browns are 1-1 in their last 5 games against the spread
Browns are 0-1 in their road games against the spread
The totals have gone OVER in 1 of Browns' last 2 games
The totals have gone OVER in 0 of Browns' 1 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Browns	1-1	1-0	0-1	N/A	1-1
Packers	2-0	2-0	N/A	2-0	N/A

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Browns	1-1	0-1	1-0	N/A	1-1
Packers	0-2	0-2	N/A	0-2	N/A

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Browns	0-2	N/A	N/A	N/A	0-2
Packers	2-0	N/A	N/A	2-0	N/A

date	opponent	score	spread	over/under	moneyline
Sep 14th	@BAL	L 17-41	+12.5 L	O 46.5	BAL +640
Sep 7th	CIN	L 16-17	+4.5 W	U 47.5	CIN +185
Aug 23rd	LA	W 19-17	-10 L	U 37	CLE -550
Aug 16th	@PHI	W 22-13	+2.5 W	U 36.5	CLE +120
Aug 8th	@CAR	W 30-10	+5.5 W	O 33.5	CLE +210

Mike Hall
DT
Hall is out with knee
Out

Zayne Anderson
S
Anderson is questionable with knee
Questionable
Christian Watson
WR
Watson is out with knee
Out
Jayden Reed
WR
Reed is out with collarbone
Out
MarShawn Lloyd
RB
Lloyd is out with hamstring
Out
Barryn Sorrell
DE
Sorrell is questionable with knee
Questionable

See more NFL Injuries

passing yards
Joe Flacco
489
pyds
passing touchdowns
Joe Flacco
2
ptd
rushing yards
Quinshon Judkins
61
ryds
rushing touchdowns
Raheim Sanders
1
rtd

	Starter	2ND	3RD	4TH
QB	Joe Flacco	Dillon Gabriel	Shedeur Sanders	Deshaun Watson
RB	Jerome Ford	Quinshon Judkins	Dylan Sampson	Ahmani Marshall
WR	Jamari Thrash	DeAndre Carter	Gage Larvadain	Cade McDonald
TE	David Njoku	Harold Fannin	Blake Whiteheart	Brenden Bates	Sal Cannella
LT	Dawand Jones	Cornelius Lucas
LG	Joel Bitonio	Teven Jenkins
C	Ethan Pocic	Luke Wypler
RG	Wyatt Teller	Zak Zinter
RT	Jack Conklin
LDE	Alex Wright	Isaiah McGuire	Julian Okwara	K.J. Henry
RDE	Myles Garrett	Joe Tryon-Shoyinka	Cameron Thomas
WLB	Devin Bush	Jerome Baker	Winston Reid
MLB	Carson Schwesinger	Mohamoud Diabate	Easton Mascarenas-Arnold
LCB	Denzel Ward	Dom Jones
SS	Grant Delpit	Rayshawn Jenkins	Donovan McMillon
FS	Ronnie Hickman	Damontae Kazee	Christopher Edmonds
RCB	Greg Newsome
P	Corey Bojorquez
H	Corey Bojorquez
PR	DeAndre Carter	Gage Larvadain	Kaden Davis
KR	DeAndre Carter	Kaden Davis
LS	Rex Sunahara
RWR	Jerry Jeudy	Isaiah Bond	Kaden Davis
NB	Cameron Mitchell	Myles Harden	LaMareon James
DT	Mason Graham	Mike Hall	Sam Kamara	Ralph Holley
LWR	Cedric Tillman	David Bell
NT	Maliek Collins	Shelby Harris	Adin Huntington
K	Andre Szmyt