Bills vs. Lions Betting Guide: How to Play This Over/Under in Detroit
Steve Mitchell-USA TODAY Sports. Pictured: Buffalo Bills outside linebacker Matt Milano (left) defensive end Trent Murphy (center) and cornerback Tre’Davious White (right).
Buffalo Bills at Detroit Lions
- Spread: Bills -2
- Over/Under: 42
- Kickoff: 8 p.m. ET
The Bills face the Lions in one of two matchups scheduled for Friday night. Let’s start with a look at key storylines and actionable betting takeaways for both teams.
The Bills might just have the single-most underrated defense in the entire league.