Los Angeles Rams vs. San Francisco 49ers Odds, Pick: The Big Sunday Night Football Edge Sharps Are Betting

Los Angeles Rams vs. San Francisco 49ers Odds, Pick: The Big Sunday Night Football Edge Sharps Are Betting article feature image
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Photo by Thearon W. Henderson/Getty Images. Pictured: Ross Dwelley #82 of the San Francisco 49ers

  • The Los Angeles Rams will battle the San Francisco 49ers in an NFC West battle on Sunday Night Football.
  • Sharps have jumped on this game, heavily betting one side on the spread.
  • Check out where sharp bettors have put their money below.

Rams vs. 49ers Betting Odds

Rams Odds-3 
49ers Odds+3 
Over/Under51.5 
Time/Channel 8:20 p.m. ET, NBC

Data as of Sunday at 8:30 a.m. ET.

Sign up for a FREE Trial of our NFL PRO Report, which highlights key factors that provide betting edges — like sharp action, large wagers, historically-profitable betting systems, model projections and expert picks.


When it comes to signals, our NFL PRO Report saved the best for last on Sunday.

Tonight's 49ers vs. Rams Week 6 matchup checks off all five PRO Report boxes, including a 5.6% edge according to The Action Network's new PRO Model Projections.

Let's examine which side of 49ers vs. Rams is popping with value ahead of Sunday Night Football.

49ers vs. Rams Betting Pick

Sharp Action

The 49ers vs. Rams spread sat at San Francisco +3.5 earlier in the week, and sharps jumped all over that number.

Seven separate instances of smart money have come in on San Fran, explaining exactly why this spread is now +3 across the market with a handful of shops, like FanDuel, already down to +2.5.

[Track sharp action for every NFL Week 6 game now by signing up for a FREE PRO Trial.]

Big Money

With professional bettors often comes big money, and that's the case in this matchup.

The 49ers have attracted 54% of the money on just 42% of the bets, confirming that the larger-sized wagers have come down on San Francisco.

PRO Systems

Not only are sharps playing the Niners, but historical data likes their chances to cover as well.

Our Fade Covering Teams PRO System is 317-246-17 (56%) against the spread since 2005 by fading teams overvalued by the market. San Francisco is one of four system matches for Sunday's Week 6 games.

Model Projections

The Action Network's NFL betting model projects this spread to be 49ers +0.3, indicating there's plenty of value in San Fran +3 in a game our numbers essentially see as a pick'em.

Top Experts

Six of our experts have piled on the home underdog as well, giving San Francisco a clean PRO Report sweep.

PRO Report Angle: 49ers +3

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