Week 1 NFL Odds, Picks & Predictions: Your Guide To Betting Sunday’s Games

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Stephen Lew/Icon Sportswire via Getty Images. Pictured: Michael Thomas

The first NFL Sunday of the season is finally here.

To help you get ready, we’ve outlined all our actionable advice for the main slate — from game previews and our favorite picks of the slate to power ratings edges and survivor pool recommendations.

Find everything you need to bet Sunday’s games below, including information on how and where to bet.

Week 1 NFL Odds

Odds below as of 8:30 a.m. ET and via DraftKings, where you can get up to a $1,000 sign-up bonus. Compare real-time lines from various sportsbooks using our NFL Odds page.

Spread
Total
Kickoff
Preview
Chargers -2.5 at Bengals [Bet Now]
42 [Bet Now]
4:05 p.m. ET
Read More
Buccaneers at Saints -3.5 [Bet Now]
47.5 [Bet Now]
4:25 p.m. ET
Read More
Cardinals at 49ers -6.5 [Bet Now]
48 [Bet Now]
4:25 p.m. ET
Read More
Packers -2.5 at Vikings [Bet Now]
45 [Bet Now]
1 p.m. ET
Read More
Bears at Lions -2.5 [Bet Now]
42.5 [Bet Now]
1 p.m. ET
Read More
Colts -8 at Jaguars [Bet Now]
46 [Bet Now]
1 p.m. ET
Read More
Eagles -5.5 at Washington [Bet Now]
42 [Bet Now]
1 p.m. ET
Read More
Browns at Ravens -7.5 [Bet Now]
47.5 [Bet Now]
1 p.m. ET
Read More
Jets at Bills -6 [Bet Now]
39.5 [Bet Now]
1 p.m. ET
Read More
Raiders -3 at Panthers [Bet Now]
48 [Bet Now]
1 p.m. ET
Read More
Seahawks -1.5 at Falcons [Bet Now]
49 [Bet Now]
1 p.m. ET
Read More

Week 1 NFL Picks

Below are our staff’s favorite bets for Sunday. Click on a pick to read more.

PICK
KICKOFF
BET NOW AT
Bengals +3 vs. Chargers
4:05 p.m. ET
FanDuel
Cardinals +7 vs. Chargers
4:25 p.m. ET
WilliamHill
Seahawks -1.5 at Falcons
1 p.m. ET
DraftKings
Packers-Vikings Under 45.5
1 p.m. ET
BetMGM
Colts -8 at Jaguars
1 p.m. ET
FanDuel
Bears +120 at Lions
1 p.m. ET
FanDuel
Panthers +3 vs. Raiders
1 p.m. ET
BetMGM

Week 1 NFL Power Ratings

Sean Koerner, our Director of Predictive Analytics, reveals his biggest betting edges for Sunday based on his Week 1 projections. Read about his five best bets.

We’re giving away a free glimpse into our consensus power ratings, which power the model projections in our new NFL PRO Report, a tool that automatically highlights the biggest betting edges across multiple of categories. See our projected spreads for every game.

Week 1 NFL Injuries

We’re tracking all the key injuries with real-time updates throughout Sunday as final actives/inactives are announced. Find the latest news.

Week 1 NFL Pick ‘Em Rankings

Straight up. Against the spread. Whether you’re playing in your office’s (virtual) pool or in a higher-stakes contest, Sean Koerner has you covered with his Week 1 Pick ‘Em Confidence Ratings.

Week 1 NFL Survivor Pool Picks

It’s Week 1. All the teams are on the board. Who do you go with? Travis Reed outlines the best survivor pool strategy and picks.

Week 1 NFL Prop Bets

Ten unders. Four first touchdown scorer. Three overs. Sean Koerner highlights his 17 (!) favorite NFL prop bets for Sunday’s main slate.

Five more props are showing value according to our FantasyLabs NFL Player Prop Tool, which is powered by Koerner’s projections. Find out which.

How & Where To Bet On Week 1 NFL

You can find reviews of the best online sportsbooks in your states, their latest promos and more in this hub.

Legal online sports betting is currently available in the following states:

And here are some of the top online sportsbooks:

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