Week 2 NFL Odds: Opening Spreads & Totals For Every Game

Week 2 NFL Odds: Opening Spreads & Totals For Every Game article feature image
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Rob Carr/Getty Images. Pictured: Lamar Jackson, Deshaun Watson

Favorites went 6-6 against the spread while overs went 8-4 on the first NFL Sunday of the 2020 season (excluding Sunday Night Football). So what can we expect heading into Week 2?

Books are already rolling out their opening lines. You’ll find spreads and totals for every game, starting with the Thursday Night Football matchup between the Bengals and Browns and ending with the Monday Night Football showdown between the Saints and Raiders.

Week 2 NFL Odds: Spreads & Totals


Odds as of 8 p.m. ET on Sunday and via DraftKings. Get up to a $1,000 sign-up bonus at DraftKings today or see more offers and reviews for the best online sportsbooks.


Cincinnati Bengals at Cleveland Browns

Thursday Night Football

  • Odds: Browns -6.5 [BET NOW]
  • Over/Under: 45.5 [BET NOW]
  • Time: 8:20 p.m. ET on Sept. 17
  • TV Channel: NFL Network

San Francisco 49ers at New York Jets

  • Odds: 49ers -6.5 [BET NOW]
  • Over/Under: 43.5 [BET NOW]
  • Time: 1 p.m. ET on Sept. 20
  • TV Channel: FOX

Buffalo Bills at Miami Dolphins

  • Odds: Bills -4 [BET NOW]
  • Over/Under: 42.5 [BET NOW]
  • Time: 1 p.m. ET on Sept. 20
  • TV Channel: CBS

Detroit Lions at Green Bay Packers

  • Odds: Packers -5.5 [BET NOW]
  • Over/Under: 46 [BET NOW]
  • Time: 1 p.m. ET on Sept. 20
  • TV Channel: FOX

Minnesota Vikings at Indianapolis Colts

  • Odds: Colts -3 [BET NOW]
  • Over/Under: 46 [BET NOW]
  • Time: 1 p.m. ET on Sept. 20
  • TV Channel: FOX

Carolina Panthers at Tampa Bay Buccaneers

  • Odds: Buccaneers -8 [BET NOW]
  • Over/Under: 48.5 [BET NOW]
  • Time: 1 p.m. ET on Sept. 20
  • TV Channel: FOX

Los Angeles Rams at Philadelphia Eagles

  • Odds: Eagles -2.5 [BET NOW]
  • Over/Under: 48.5 [BET NOW]
  • Time: 1 p.m. ET on Sept. 20
  • TV Channel: FOX

Jacksonville Jaguars at Tennessee Titans

  • Odds: Titans -10.5 [BET NOW]
  • Over/Under: 42.5 [BET NOW]
  • Time: 1 p.m. ET on Sept. 20
  • TV Channel: CBS

Atlanta Falcons at Dallas Cowboys

  • Odds: Cowboys -7 [BET NOW]
  • Over/Under: 50.5 [BET NOW]
  • Time: 1 p.m. ET on Sept. 20
  • TV Channel: FOX

Denver Broncos at Pittsburgh Steelers

  • Odds: Steelers -6.5 [BET NOW]
  • Over/Under: 43 [BET NOW]
  • Time: 1 p.m. ET on Sept. 20
  • TV Channel: CBS

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New York Giants at Chicago Bears

  • Odds: Bears -5.5 [BET NOW]
  • Over/Under: 43 [BET NOW]
  • Time: 1 p.m. ET on Sept. 20
  • TV Channel: CBS

Washington Football Team at Arizona Cardinals

  • Odds: Cardinals -6.5 [BET NOW]
  • Over/Under: 46 [BET NOW]
  • Time: 4:05 p.m. ET on Sept. 20
  • TV Channel: FOX

Kansas City Chiefs at Los Angeles Chargers

  • Odds: Chiefs -7 [BET NOW]
  • Over/Under: 50.5 [BET NOW]
  • Time: 4:25 p.m. ET on Sept. 20
  • TV Channel: CBS

Baltimore Ravens at Houston Texans

  • Odds: Ravens -6.5 [BET NOW]
  • Over/Under: 53.5 [BET NOW]
  • Time: 4:25 p.m. ET on Sept. 20
  • TV Channel: CBS

New England Patriots at Seattle Seahawks

Sunday Night Football

  • Odds: Seahawks -3.5 [BET NOW]
  • Over/Under: 44.5 [BET NOW]
  • Time: 8:20 p.m. ET on Sept. 20
  • TV Channel: NBC

New Orleans Saints at Las Vegas Raiders

Monday Night Football

  • Odds: Saints -5.5 [BET NOW]
  • Over/Under: 50.5 [BET NOW]
  • Time: 8:15 p.m. ET on Sept. 21
  • TV Channel: ESPN

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