The Cincinnati Reds host the Athletics on August 5, 2026. First pitch from Great American Ball Park is scheduled for 6:40 p.m. EDT. The game will be broadcast on NBCS-CA.
The Reds are favored by -130 on the moneyline and by -1.5 on the run line. The Athletics are +120 on the moneyline and +1.5 on the run line. The total is set at 9.5 runs.
Find my MLB picks and Athletics vs Reds prediction below, as well as probable pitchers, weather report, and more.
Athletics vs Reds Prediction
- Athletics vs Reds Pick: Athletics Moneyline (+120)
My Athletics vs Reds best bet is on the Athletics to win outright. Make sure to find the best odds by checking our live MLB odds page.
Athletics vs Reds Odds
| Athletics Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -176 | 9.5 -122o / -100u | +120 |
| Reds Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +146 | 9.5 -122o / -100u | -130 |
- Athletics vs Reds moneyline: Athletics +120, Reds -130
- Athletics vs Reds over/under: 9.5 (-122o / -100u)
- Athletics vs Reds spread: Reds -1.5 (+146), Athletics +1.5 (-176)
Athletics vs Reds Probable Pitchers
| LHP Jacob Lopez (ATH) | Stat | RHP Rhett Lowder (CIN) |
|---|---|---|
| 5-4 | W-L | 3-7 |
| 0.1 | fWAR (FanGraphs) | 1.1 |
| 5.79/3.67 | ERA / xERA | 5.42/5.23 |
| 5.51/5.66 | FIP / xFIP | 4.46/4.75 |
| 5.8% | K-BB% | 8.8% |
| 31.8% | GB% | 42.0% |
| .303 | BABIP | .310 |
| 95 | Stuff+ | 86 |
| 100 | Location+ | 102 |
Athletics vs Reds MLB Betting Preview
The Athletics are looking to break out of a six-game skid when they take on the Cincinnati Reds in the second matchup of this interleague series.
The A's enter the contest with a 45-68 overall record, including a 24-32 mark on the road. Power plays a central role in their success, evidenced by their 23-12 record when hitting at least two home runs in a game.
Cincinnati brings a 54-58 overall record and a 27-31 record on their home field into Wednesday's action. The Reds boast a formidable lineup that ranks seventh in Major League Baseball with 145 total home runs on the year.
The pitching matchup features left-hander Jacob Lopez taking the mound against right-hander Rhett Lowder.
Lopez carries a 5-4 record, a 5.79 ERA, a 1.67 WHIP, and 61 strikeouts on the season, but he has quietly turned things around with a 3.26 ERA across his past five starts since returning from Triple-A in early July.
Lowder stands at 3-7 with a 5.42 ERA, a 1.52 WHIP, and 70 strikeouts overall, though he has proven far more effective in familiar territory, owning a 3.07 ERA over nine appearances (six starts) in Cincinnati this year.
Athletics vs Reds Pick, Betting Analysis
While Cincinnati opens as the home favorite, taking the Athletics on the moneyline as +120 road underdogs offers great situational value.
This recommendation heavily relies on the "Road Dogs Interleague" system outlined by betting analyst Evan Abrams. In Major League Baseball, visiting underdogs playing non-conference interleague matchups are routinely undervalued by oddsmakers due to public bias toward home teams and a lack of familiarity between interleague opponents.
Even though interleague road underdogs win just 43.3% of their games straight up, backing them on the moneyline has produced a consistent 4.6% return on investment for bettors since 2016.
Given Jacob Lopez's improved pitching since July and the A's explosive power upside, backing them to pull off the road upset at +120 offers the best overall value on Wednesday's board.
Pick: Athletics Moneyline (+120)
