The Houston Astros host the Athletics on August 21, 2026. First pitch from Daikin Park is scheduled for 8:10 p.m. EDT. The game will be broadcast on NBCS-CA.
The Astros are favored by -177 on the moneyline and by -1.5 on the run line. The Athletics are +165 on the moneyline and +1.5 on the run line. The total is set at 8 runs.
Find our MLB picks and Athletics vs Astros prediction below, as well as probable pitchers, weather report, and more.
Athletics vs Astros Prediction
- Athletics vs Astros Pick: Athletics ML (+165)
Our Athletics vs Astros best bet is on A's to win outright. Make sure to find the best odds by checking our live MLB odds page.
Athletics vs Astros Odds
| Athletics Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -141 | 8 -111o / -109u | +165 |
| Astros Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +117 | 8 -111o / -109u | -177 |
- Athletics vs Astros moneyline: Athletics +165, Astros -177
- Athletics vs Astros over/under: 8 (-111o / -109u)
- Athletics vs Astros spread: Athletics +1.5 (-141), Astros -1.5 (+117)
Athletics vs Astros Probable Pitchers
| J.T. Ginn (RHP, ATH) | Stat | Hayden Wesneski (RHP, HOU) |
|---|---|---|
| 8-7 | W-L | 2-1 |
| 1.6 | fWAR (FanGraphs) | 0.4 |
| 3.53 / 3.97 | ERA / xERA | 5.16 / 4.46 |
| 4.16 / 4.21 | FIP / xFIP | 3.71 / 4.36 |
| 11.4 | K-BB% | 11.6 |
| 45.7% | GB% | 39.7 |
| .256 | BABIP | .313 |
| 93 | Stuff+ | 93 |
| 101 | Location+ | 102 |
Athletics vs Astros MLB Betting Preview
Sean Zerillo's projections show solid value on the Athletics moneyline tonight against the Astros.
If you want to dive deeper into this matchup, it'd be wise to check out BARTOLO, Zerillo's new PRO baseball tool that gives you access to all the input data he uses to project games every day.
Athletics vs Astros Pick, Betting Analysis
BARTOLO projects a 5.2% edge on the Athletics moneyline for tonight's matchup, the second largest on Friday's MLB slate.
The visitors' defense gets the best grade of the two lineups: an A.
J.T. Ginn will start for the A's, and despite some recent struggles, his ERA this season is 3.53 with solid expected metrics.
Hayden Wesneski, by contrast, is a liability for the Astros and the main reason to back the Athletics at a great price.
Wesneski is coming off an awful start against a slumping Mariners lineup that broke out with seven hits and five runs in the four innings he pitched.
The Astros starter's splits are also worrisome, with a 6.30 ERA at home and a 5.16 ERA at night.
Plus, the Houston lineup is going through a rough spell with just nine runs combined in its last four games.
At such excellent odds, backing the A's is a great choice.
Pick: Athletics ML (+165, DraftKings)
