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Red Sox vs Orioles Prediction, Pick, MLB Odds for Sunday, September 6

Red Sox vs Orioles Prediction, Pick, MLB Odds for Sunday, September 6 article feature image
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Vincent Carchietta-Imagn Images. Pictured: Red Sox DH/OF Roman Anthony

The Baltimore Orioles host the Boston Red Sox on September 6, 2026. First pitch from Oriole Park at Camden Yards is scheduled for 1:35 p.m. ET. The game will be broadcast on NESN.

The Red Sox are favored by -135 on the moneyline and by -1.5 on the run line. The Orioles are +115 on the moneyline and +1.5 on the run line. The total is set at 7.5 runs.

Find our MLB picks and Red Sox vs Orioles prediction below, as well as probable pitchers, weather report, and more.


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Red Sox vs Orioles Prediction

  • Red Sox vs Orioles Pick: Roman Anthony 1+ Doubles (+375)

Our Red Sox vs Orioles best bet is on Roman Anthony to hit a double this afternoon. Make sure to find the best odds by checking our live MLB odds page.


Red Sox vs Orioles Odds

Red Sox Logo
Sunday, Sep 6
1:35 p.m. ET
NESN
Orioles Logo
Red Sox Odds
SpreadTotalMoneyline
-1.5
+125
7.5
-110o / -110u
-135
Orioles Odds
SpreadTotalMoneyline
+1.5
-150
7.5
-110o / -110u
+115
Odds via bet365. Get up-to-the-minute MLB odds here.
bet365 Logo
  • Red Sox vs Orioles moneyline: Red Sox -135, Orioles +115
  • Red Sox vs Orioles over/under: 7.5 (-110o / -110u)
  • Red Sox vs Orioles spread: Red Sox -1.5 (+125), Orioles +1.5 (-150)

Red Sox vs Orioles Probable Pitchers

Payton Tolle (LHP, BOS)StatKyle Bradish (RHP, BAL)
8-6W-L7-12
3.3fWAR (FanGraphs)1.9
3.23 / 2.73ERA / xERA4.01 / 4.29
3.28 / 3.64FIP / xFIP4.10 / 4.15
20.8K-BB%11.5
36.1GB%44.6
.281BABIP.313
114Stuff+100
100Location+99

Red Sox vs Orioles MLB Betting Preview

Red Sox rising star Roman Anthony is priced at bet365 at +500, implying a 21% chance to hit a double this afternoon in Baltimore.

However, Action PRO projects him at 0.35 doubles, or a fair price closer to +186.

This gives us our second-largest edge on this matchup, with 8.5% and a B- grade on our system, to back the Boston outfielder and DH to hit one today against the Orioles.

After coming back from the IL in August, Anthony is averaging .323 and delivering on the promise of his first season.

Right away, he hit two doubles in straight games, but has yet to record a two-base hit this month, which should be coming any time soon.

Plus, the left-handed hitter has an excellent split in day games with a .294 average.

At a great price, let's back him to hit a double today.

Pick: Roman Anthony 1+ Doubles (+375, bet365)


Red Sox vs Orioles Weather


Get the latest coverage on MLB Weather.


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