The San Diego Padres host the Chicago Cubs on April 28, 2026. First pitch from Petco Park is scheduled for 9:40 p.m. EDT. The game will be broadcast on SDPA.
The Cubs are favored by -118 on the moneyline and by -1.5 (+134) on the run line. The Padres are +100 on the moneyline and +1.5 (-162) on the run line. The total is set at 8.5 runs.
Find my MLB picks and Cubs vs Padres prediction below, as well as probable pitchers, weather report, and more.
Cubs vs Padres Prediction
- Cubs vs Padres Pick: Over 8.5
My Cubs vs Padres best bet is on the Over. Make sure to find the best odds by checking our live MLB odds page.
Cubs vs Padres Odds
| Cubs Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +134 | 8.5 -100o / -122u | -118 |
| Padres Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -162 | 8.5 -100o / -122u | +100 |
- Cubs vs Padres moneyline: Cubs -118, Padres +100
- Cubs vs Padres over/under: 8.5 (-100 / -122)
- Cubs vs Padres spread: Cubs -1.5 (+134), Padres +1.5 (-162)
Cubs vs Padres Probable Pitchers
| Edward Cabrera | Stat | Walker Buehler |
|---|---|---|
| 2-0 | W-L | 1-2 |
| 0.5 | fWAR (FanGraphs) | 0.4 |
| 2.73 / 3.72 | ERA / xERA | 5.75 / 4.97 |
| 3.63 / 4.22 | FIP / xFIP | 3.28 / 3.70 |
| 9.2 | K-BB% | 12.0 |
| 41.7 | GB% | 48.4 |
| .262 | BABIP | .377 |
| 92 | Stuff+ | 94 |
| 103 | Location+ | 95 |
Cubs vs Padres MLB Betting Preview
Chicago Cubs Betting Preview
The Cubs have dropped three games in a row. During this stretch, they've allowed at least six runs in each game. Their starting pitchers have gone 5 1/3 innings or fewer in each matchup.
This has put added stress on their bullpen, which is already missing Danny Palencia, Caleb Thielbar, and Riley Martin. Their top reliever right now, Ben Brown, threw 43 pitches last night, while Phil Maton was at 28. Each may be unavailable on Tuesday.
That puts a lot of pressure on the starter, Edward Cabrera.
It's been a disappointing start for Cabrera despite the 2.73 ERA. His strikeout rate is down from 25.8% to 18.5%, while his 4.58 SIERA highlights how the underlying metrics don't support his current results.
It's a tough spot against a Padres team that ranks 13th among MLB lineups in wRC+ against right-handers and ninth in the last seven days.
San Diego Padres Betting Preview
The Padres have won seven of their past 10 games, putting them at 19-9 on the season.
They'll send out Walker Buehler on Tuesday, who is coming off a rough outing at Coors Field, where he allowed four runs on eight hits across only 2 2/3 innings.
However, Buehler has been pretty good in his last two home starts, combining for two earned runs allowed in 11 innings against the Mariners and the Rockies.
Like the Cubs, the Padres' bullpen is also taxed in this game, with Mason Miller (27 pitches), Adrian Morejon (27 pitches), and Jason Adam (17 pitches) each making appearances last night.
With Buehler going five innings or fewer in four of five starts, San Diego may need to rely on its relievers once again here.
Cubs vs Padres Pick, Betting Analysis
Edward Cabrera (4.58 SIERA) is taking on Walker Buehler (4.05 SIERA).
The Cubs' bullpen is taxed, having used Ben Brown and Phil Maton last night, with Danny Palencia, Caleb Thielbar, and Riley Martin injured.
The same goes for the Padres, who used Mason Miller, Adrian Morejon, and Jason Adam last night.
Each team ranks in the top 10 in wRC+ in the last seven days.
When you consider each of these factors, you come away liking the Over.
Pick: Over 8.5
