The Arizona Diamondbacks (62-66) host the Cincinnati Reds (67-61) on August 22, 2025. First pitch from Chase Field is scheduled for 9:40 p.m. EDT; the game will be broadcast on FDSOH.
Find my MLB betting preview and Reds vs Diamondbacks prediction below with odds, as well as probable pitchers, betting trends, injury reports and more.
Our Reds vs Diamondbacks Prediction
- Reds vs Diamondbacks pick: Over 9
Our Reds vs Diamondbacks prediction is on the over 9 total runs, with the best odds currently on Fanatics. Make sure to find the best odds by checking our live MLB odds page.
Reds vs Diamondbacks Odds
| Reds Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -181 | 9 -110o / -110u | +113 |
| Diamondbacks Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +148 | 9 -110o / -110u | -137 |
Reds vs Diamondbacks Projected Starting Pitchers
| RHP Zack Littell (CIN) | Stat | RHP Ryne Nelson (ARI) |
|---|---|---|
| 9-8 | W-L | 6-3 |
| 1.5 | fWAR (FanGraphs) | 1.3 |
| 3.52/4.52 | ERA /xERA | 3.58/4.03 |
| 4.65/4.22 | FIP / xFIP | 3.76/4.01 |
| 1.11 | WHIP | 1.07 |
| 12.9% | K-BB% | 15.1% |
| 41.6% | GB% | 39.2% |
| 87 | Stuff+ | 108 |
| 104 | Location+ | 100 |
Reds vs Diamondbacks Prediction, Pick
The Arizona Diamondbacks host the Cincinnati Reds on Friday night in the opener of a three-game set. Arizona is a -137 favorite on the moneyline, while Cincinnati is +113 to pull off the upset. Oddsmakers have set the total at 9 runs.
Both teams enter off series wins, as the Diamondbacks took two of three from Cleveland while the Reds did the same against the Angels.
Zack Littell will get the start for Cincinnati after tossing six strong innings of one-run ball with three strikeouts in his last outing. Arizona counters with Ryne Nelson, who sits at 99 strikeouts this season and is looking to help the Diamondbacks become the first team with five pitchers to hit the 100-K mark.
While both starters have momentum, the environment sets up well for offense. Evan Abrams’ “Late Season Overs, Lower Totals” system has shown value in hitter-friendly parks like Arizona when totals close at 10.5 runs or lower.
Late in the season, conditions such as dry desert heat and volatile bullpens often lead to more scoring than markets expect.
With this total sitting at just 9, the matchup fits the profile for runs to come in bunches.
Pick: Over 9 (-110, Fanatics)
Reds vs Diamondbacks Betting Trends
