Guardians vs Tigers Predictions, Parlay, Picks, Odds for Thursday, May 22

Guardians vs Tigers Predictions, Parlay, Picks, Odds for Thursday, May 22 article feature image
Credit:

Ken Blaze-Imagn Images. Pictured: Cleveland’s Steven Kwan.

The Detroit Tigers host the Cleveland Guardians on May 22, 2025. First pitch from Comerica Park is scheduled for 6:40 p.m. ET; the game will be broadcast on CLEG and MLB.TV.

The Tigers enter as -130 favorites on the moneyline with the over/under sitting at 8.

Read our Guardians vs Tigers prediction and MLB same-game parlay picks below.

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Guardians vs Tigers Prediction

  • Under 8
  • Steven Kwan 1+ Hits

Parlay Odds: +170 (BetMGM)


Guardians vs Tigers Odds

Guardians Logo
Thursday, May 22
6:40 p.m. ET
MLB.TV
Tigers Logo
Guardians Odds
Run LineTotalMoneyline
+1.5
-200
8
-105o / -115u
+110
Tigers Odds
Run LineTotalMoneyline
-1.5
+165
8
-105o / -115u
-130
Odds via BetMGM. Get up-to-the-minute MLB odds here.
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Guardians vs Tigers Preview, Parlay Picks

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Under 8

We will see an outstanding pitching matchup in tonight’s game between the Guardians and Tigers.

Cleveland will send right-hander Tanner Bibee to the mound to take on Detroit's Jack Flaherty.

Both pitchers enter the matchup with ERAs north of 4.00 but are better than their numbers indicate. We will see both pitchers get back on track tonight, leading to a low-scoring affair


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Steven Kwan 1+ Hits

Kwan has experience against Flaherty. The Guardians outfielder has collected three hits in nine career at-bats against Flaherty.

Kwan has also cashed this prop in six of his last nine games and leads the team with 60 hits this season.


Guardians vs Tigers Parlay

  • Under 8
  • Steven Kwan 1+ Hits

Parlay Odds: +170 (BetMGM)


Guardians vs Tigers Betting Trends


Guardians vs Tigers Weather


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About the Author
Matt is a Senior Betting Analyst at Action Network. He has been in the betting industry for eight years and has worked as a Lead Betting Analyst for numerous companies over the years. Matt specializes in multiple sports, including NFL, NBA, MLB, NHL, NCAAF, NCAAB, UFC, Golf and NASCAR.

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