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Guardians vs Angels Prediction, Pick, MLB Odds for Wednesday, August 26

Guardians vs Angels Prediction, Pick, MLB Odds for Wednesday, August 26 article feature image
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Photo Credit: Christopher Hanewinckel-Imagn Images
Pictured: Joey Cantillo talks with Patrick Bailey

The Los Angeles Angels host the Cleveland Guardians on August 26, 2026. First pitch from Angel Stadium is scheduled for 4:07 p.m. EDT. The game will be broadcast on ABTV.

The Guardians are favored by -134 on the moneyline and by -1.5 on the run line. The Angels are +124 on the moneyline and +1.5 on the run line. The total is set at 8.5 runs.

Find my MLB picks and Guardians vs Angels prediction below, as well as probable pitchers, weather report, and more.


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Guardians vs Angels Prediction

  • Guardians vs Angels Pick: Guardians ML (-134)

My Guardians vs Angels best bet is on Cleveland to win. Make sure to find the best odds by checking our live MLB odds page.


Guardians vs Angels Odds

Guardians Logo
Wednesday, Aug 26
4:07 p.m. ET
ABTV
Angels Logo
Guardians Odds
SpreadTotalMoneyline
-1.5
+108
8.5
-115o / -105u
-134
Angels Odds
SpreadTotalMoneyline
+1.5
-130
8.5
-115o / -105u
+124
Odds via FanDuel. Get up-to-the-minute MLB odds here.
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  • Guardians vs Angels moneyline: Guardians -134, Angels +124
  • Guardians vs Angels over/under: 8.5 (-115o / -105u)
  • Guardians vs Angels spread: Guardians -1.5 (+108), Angels +1.5 (-130)

Guardians vs Angels Probable Pitchers

Joey CantilloStatGrayson Rodriguez
9-7W-L4-5
1.9fWAR (FanGraphs)0.3
3.73 / 3.91ERA / xERA6.41 / 5.77
3.87 / 3.89FIP / xFIP4.80 / 4.52
14.4K-BB%10.4
45.6GB%36.6
.326BABIP.318
95Stuff+104
97Location+98

Guardians vs Angels MLB Betting Preview

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Guardians vs Angels Pick, Betting Analysis

The Angels are a total train wreck. After blowing a 5-0 lead on Tuesday, the Halos have the odds stacked against them on Wednesday, with the Guardians sitting as -144 favorites. I think that line is light with all the edges the Guardians have.

On the mound for the Guardians is left-hander Joey Cantillo, who has a 3.73 ERA with a 3.91 xERA and 3.87 FIP. For Cantillo, much of his success revolves around players chasing his curveball. He throws a big, looping 12-6 curve over 30% of the time — leading to his 9.94 K/9 and dicey 4.35 BB/9.

Anaheim will chase Cantillo's curveball plenty, as it has a horrid plate approach, running a 7% walk rate (29th) and a 25% strikeout rate (28th) since July 20th.

Throwing for the Angels is former top prospect Grayson Rodriguez, who can only hang on that status for so long. He's been a wreck this year, posting a 6.41 ERA with a 5.77 xERA and 4.81 FIP.

Rodriguez has a career-worst 8.32 K/9, 4.09 BB/9, and 1.36 HR/9. For a pitcher coming off arm injuries, having career-worst numbers in those categories is less than ideal.

This Guardians lineup should fare well against Rodriguez. They rank 21st in the league with a 92 wRC+ in their last 28 games.

Cleveland might lack power, but it punches out just 18% of the time — which should force Rodriguez to throw more pitches. And once he turns it over to the bullpen, the Guardians could pour it on.

Picks: Guardians ML (-134)


Guardians vs Angels Weather


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