The Minnesota Twins host the Houston Astros on May 20, 2026. First pitch from Target Field is scheduled for 1:40 p.m. ET. The game will be broadcast on MNNT.
The Twins are favored by -152 on the moneyline and by -1.5 on the run line. The Astros are +128 on the moneyline and +1.5 on the run line. The total is set at 8 runs.
Find our MLB picks and Astros vs Twins prediction below, as well as probable pitchers, weather report, and more.
Astros vs Twins Prediction
- Astros vs Twins Pick: Under 8 (-110)
Our Astros vs Twins best bet is Under 8 total runs in this game. Make sure to find the best odds by checking our live MLB odds page.
Astros vs Twins Odds
| Astros Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -164 | 8 -110o / -110u | +128 |
| Twins Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +136 | 8 -110o / -110u | -152 |
- Astros vs Twins moneyline: Astros +128, Twins -152
- Astros vs Twins over/under: 8 (-110o / -110u)
- Astros vs Twins spread: Astros +1.5 (-164), Twins -1.5 (+136)
Astros vs Twins Probable Pitchers
| RHP Mike Burrows (HOU) | Stat | RHP Joe Ryan (MIN) |
|---|---|---|
| 2-5 | W-L | 2-3 |
| 0.2 | fWAR (FanGraphs) | 1.5 |
| 5.72 / 3.94 | ERA / xERA | 3.20 / 3.14 |
| 5.00 / 4.24 | FIP / xFIP | 2.84 / 3.77 |
| 13.1 | K-BB% | 18.7 |
| 36.8 | GB% | 39.1 |
| .342 | BABIP | .260 |
| 94 | Stuff+ | 107 |
| 99 | Location+ | 106 |
Astros vs Twins MLB Betting Preview
Our own Sean Zerillo projects an edge on the total for this matchup.
While the consensus line sits at 8, Zerillo projects around 7.15 runs for this game, representing a 4.7% edge against the market, making the under the best choice with a B- grade on our system.
As a reminder, you can see all of Zerillo's MLB game projections with an Action PRO Subscription. Find his projected lines every day on the PRO Projections tab.
Astros vs Twins Pick, Betting Analysis
Mike Burrows' awful last outing might sway people toward the over, but the Astros SP had three excellent starts before that disaster, and the Twins offense is not exactly a powerhouse.
Minnesota ranks 19th in wRC+ against right-handed pitchers and is also 19th at home games.
Plus, they will send ace Joe Ryan to the mound against a Houston lineup that is in the middle of a significant slump.
The Astros rank 29th in wRC+ in the past 14 days with a 69 rating.
Ryan hasn't given up more than one run in his last two starts, with six hits allowed and 12 strikeouts in 12 innings combined.
Plus, with a slight wind blowing in this afternoon, the under offers real value.
Pick: Under 8 (-110, FanDuel)
