The Seattle Mariners host the Los Angeles Angels on September 12, 2025. First pitch from T-Mobile Park is scheduled for 10:10 p.m. EDT; the game will be broadcast on Apple TV+.
Yusei Kikuchi will start for the Angels, and Luis Castillo will take the mound for the Mariners in the second game of this series tonight.
Find my MLB betting preview and Angels vs Mariners prediction below, as well as probable pitchers, betting trends, injury reports and more.
My Angels vs Mariners Prediction
- Angels vs Mariners pick: Angels ML +155
My Angels vs Mariners best bet is on the Angels moneyline. Make sure to find the best odds by checking our live MLB odds page.
Angels vs Mariners Odds
| Angels Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -145 | 7.5 -118o / -102u | +155 |
| Mariners Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +118 | 7.5 -118o / -102u | -185 |
Angels vs Mariners Projected Starting Pitchers
| LHP Yusei Kikuchi (LAA) | Stat | RHP Luis Castillo (SEA) |
|---|---|---|
| 6-11 | W-L | 9-8 |
| 2.1 | fWAR (FanGraphs) | 2.0 |
| 4.18 / 4.67 | ERA / xERA | 3.85 / 4.35 |
| 4.31 / 4.30 | FIP / xFIP | 4.08 / 4.16 |
| 1.48 | WHIP | 1.27 |
| 13.3 | K-BB% | 14.7 |
| 37.5 | GB% | 42.0 |
| 95 | Stuff+ | 96 |
| 105 | Location+ | 105 |
Angels vs Mariners Preview, Prediction, Betting Analysis
This is my favorite underdog tonight: I'm going with the Angels on the moneyline against the red-hot Mariners.
Let's go over this. Seattle is now tied for the lead in the AL West with Houston. They've won six straight, including last night's extra-inning win against these Angels. I'm high on the Mariners the rest of the way. But I'm fading them tonight. It's a matchup of Yusei Kikuchi against Luis Castillo.
More than anything else, this is a public fade for me. We're looking at 79% of bets on the Mariners tonight, but just 49% of the money indicates sharps are backing the Angels tonight as well. And it makes sense.
Kikuchi has gotten roughed up for a couple of starts in a row now. He's given up seven, five, and six earned runs, respectively, in his last three starts.
Castillo's coming off a really strong start against the Braves last week, but he was fallible for a couple of starts before that.
By most metrics, Castillo's the better starting pitcher here, but it's close. Given that it's close and given that both teams absolutely burned through their entire bullpens in last night's 12-inning game, I think there's enough uncertainty in this matchup to back the underdog here, considering the number we're getting on the Angels.
We got them at +165 this morning, and it's in the +155 to +160 range at most books.
Pick: Angels ML +155 (Fanatics)
Angels vs Mariners Betting Trends
