The San Diego Padres host the Minnesota Twins on August 22, 2026. First pitch from Petco Park is scheduled for 8:40 p.m. EDT. The game will be broadcast on SDPA.
The Padres are favored by -162 on the moneyline and by -1.5 on the run line. The Twins are +136 on the moneyline and +1.5 on the run line. The total is set at 8 runs.
Find my MLB picks and Twins vs Padres prediction below, as well as probable pitchers, weather report, and more.
Twins vs Padres Prediction
- Twins vs Padres Pick: Dean Kremer Over 4.5 Strikeouts (-110 or Better)
My Twins vs Padres best bet is on Dean Kremer. Make sure to find the best odds by checking our live MLB odds page.
Twins vs Padres Odds
| Twins Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -156 | 8 -122o / -100u | +136 |
| Padres Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +130 | 8 -122o / -100u | -162 |
- Twins vs Padres moneyline: Twins +136, Padres -162
- Twins vs Padres over/under: 8 (-122 / -100)
- Twins vs Padres spread: Padres +1.5 (+156), Twins -1.5 (+120)
Twins vs Padres MLB Betting Preview
I am going to keep rolling with this until the books start bumping Dean Kremer's strikeout prop higher.
Kremer has 13 strikeouts in two starts since the Twins changed his arm angle, and his advanced metrics weren't terrible to begin with.
Even though the Padres are playing much better baseball these days than they were earlier in the season, I am fully on board with the Twins' ability to turn pitchers around.
I believe Kremer gets to five or more strikeouts for the third straight outing.
