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MLB Picks, Best Bets, Props, Predictions Today – September 19

MLB Picks, Best Bets, Props, Predictions Today – September 19 article feature image
5 min read

A full, 15-game slate is on the schedule today, and several of those matchups have massive playoff implications.

Additionally, Clayton Kershaw is set to make his final regular-season start at Dodger Stadium. Yes, there's a lot of baseball on the schedule today, but we have you covered. Our MLB betting experts and systems have sifted through the latest MLB odds and have made their predictions below.

So, continue reading for today's MLB best bets.

Quickslip

MLB Best Bets Today

The team logos in the table below represent each of the matchups that our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.

GameTime (ET)Pick
Chicago Cubs LogoCincinnati Reds Logo
6:40 p.m.
New York Yankees LogoBaltimore Orioles Logo
7:05 p.m.
San Francisco Giants LogoLos Angeles Dodgers Logo
10:10 p.m.
San Francisco Giants LogoLos Angeles Dodgers Logo
10:10 p.m.
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game.

Bet Labs' Cubs vs Reds Best Bet

Chicago Cubs Logo
Friday, September 19
6:40 p.m. ET
MLB.TV
Cincinnati Reds Logo
Under 8.5 (-114)
bet365 Logo

By Bet Labs

The "Series Unders: Off Low-Scoring Games" system focuses on regular-season MLB matchups where both teams are entering the second or later game of a series after producing minimal offense in their previous outing.

When teams come off one- or two-game streaks of low scoring, particularly early to mid-series, the market can overcorrect or undervalue continued offensive stagnation. This model anticipates that trend to persist and bets on the under when recent results and situational rhythm point to a slow-paced, low-output environment.

Overall, this system is 1405-1133-123 (55%) and has produced a 7% ROI. This season, that ROI has jumped to 9% as the system has cashed 57% of its picks (76-58-1).

MLB Icon
Evan Abrams / Bet Labs – Series Unders: Off Low-Scoring Games
betting on the Under
the series game # is between 2 and 10
the Home teams' 1 Game points scored streak is between 0 and 2
the Visiting teams' 1 Game points scored streak is between 0 and 2
the game is played during the Regular season
$18,351
WON
1407-1133-122
RECORD
55%
WIN%

Pick: Under 8.5 (-114)



Bet Labs' Yankees vs Orioles Best Bet

New York Yankees Logo
Friday, September 19
7:05 p.m. ET
MLB.TV
Baltimore Orioles Logo
Under 9 (-105)
bet365 Logo

By Bet Labs

Against Max Fried, the Orioles were shutout yesterday in this series opener, another example of their struggling offense this month.

Over the past 13 games, Baltimore has only managed to score more than five runs just once. The Orioles rank 21st in wRC+ in September, so even though they will face Will Warren, the New York starter should have no fear of this lineup.

Meanwhile, the Yankees rank eighth in wRC+ this month, but have much more of a challenge on their hands with Trevor Rogers on the mound for the Orioles.

The southpaw has been consistently great all season, posting a 1.53 ERA in the first half of the season and a 1.38 ERA after the All-Star break.

Rogers is even better at home, with a minuscule 1.10 ERA.

Pick: Under 9 (-105)



Bet Labs' Giants vs Dodgers Best Bet

San Francisco Giants Logo
Friday, September 19
10:10 p.m. ET
Apple TV+
Los Angeles Dodgers Logo
Under 8.5 (+100)
bet365 Logo

By Bet Labs

This system targets MLB regular-season games where both teams are coming off low-scoring performances (0 to 2 runs scored in their previous game) within the same series. These matchups tend to reflect strong pitching or cold offenses, and the market may not adjust the total downward enough in time.

This strategy filters for more recent seasons to reflect current scoring environments and pitcher usage trends. Betting the under in these situations has shown consistent profitability as it has gone 512-387-34 (57%) and produced a 10% ROI since we began tracking.

This season, the ROI is 9% as the system has cashed 57% of its picks (76-58-2).

MLB Icon
Evan Abrams – Under After Low Scoring Game in Series, Short Term (YEAR)
the Visiting teams' 1 Game points scored streak is between 0 and 2
the Home teams' 1 Game points scored streak is between 0 and 2
the series game # is between 2 and 100
betting on the Under
the game is played during the Regular season
the game was played during the 2025 or 2024 or 2023 or 2022 or 2021 or 2020 or 2019 or 2018 season
$9,348
WON
514-387-34
RECORD
57%
WIN%

Pick: Under 8.5 (+100)



Doug Ziefel's Giants vs Dodgers Best Bet: (EDITORIAL LANGUAGE)

San Francisco Giants Logo
Friday, September 19
10:10 p.m. ET
Apple TV+
Los Angeles Dodgers Logo
Clayton Kershaw Under 14.5 Outs Recorded (+140)
bet365 Logo

By Doug Ziefel

It seems sacrilegious to fade Clayton Kershaw in what may be his final career start at Dodger Stadium, but there is just too much working against him. This matchup is crucial for both sides, and the Dodgers can't let it slip away early if he's not sharp.

Plus, the Giants appear to have a great read on him after last week, and Kershaw has shown plenty of regression this season.

Lastly, the Dodgers are likely to give Kershaw his spotlight, which means he'll exit the game in the middle of an inning in order to receive a standing ovation from the Dodger faithful.

This very well could come at the first sign of trouble, as they don't want him to end on a sour note, especially with their long man Justin Wrobleski available in the bullpen.

Pick: Clayton Kershaw Under 14.5 Outs Recorded (+140)




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