The Cincinnati Reds host the San Diego Padres on September 2, 2026. First pitch from Great American Ball Park is scheduled for 12:40 p.m. EDT. The game will be broadcast on SDPA.
The Padres are favored by -149 on the moneyline and by -1.5 on the run line. The Reds are +123 on the moneyline and +1.5 on the run line. The total is set at 9.5 runs.
Find my MLB picks and Padres vs Reds prediction below, as well as probable pitchers, weather report, and more.
Padres vs Reds Prediction
- Padres vs Reds Picks: Fernando Tatis Jr. Over 2.5 HRR (-102), Fernando Tatis Jr. 1+ HR (+310) & Padres Moneyline (-149)
My Padres vs Reds best bets are on Fernando Tatis Hits + Runs + RBIs and Home Run props and San Diego to win outright. Make sure to find the best odds by checking our live MLB odds page.
Padres vs Reds Odds
| Padres Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +104 | 9.5 -108o / -112u | -149 |
| Reds Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -125 | 9.5 -108o / -112u | +123 |
- Padres vs Reds moneyline: Padres -149, Reds +123
- Padres vs Reds over/under: 9.5 (-108o / -112u)
- Padres vs Reds spread: Padres -1.5 (+104), Reds +1.5 (-125)
Padres vs Reds Probable Pitchers
| Casey Mize (RHP, SDP) | Stat | Brandon Williamson (LHP, CIN) |
|---|---|---|
| 5-8 | W-L | 2-3 |
| 2.8 | fWAR (FanGraphs) | -0.1 |
| 3.45/3.49 | ERA / xERA | 6.11/6.81 |
| 3.44/4.29 | FIP / xFIP | 6.06/6.46 |
| 15.5% | K-BB% | -0.8% |
| 31.8% | GB% | 33.7% |
| .268 | BABIP | .268 |
| 88 | Stuff+ | 99 |
| 107 | Location+ | 90 |
Padres vs Reds MLB Betting Preview
This afternoon’s matchup between the Reds and Padres seems to offer a favorable spot for San Diego’s red-hot lineup.
Right-hander Casey Mize will take the mound for the Padres after getting traded from Detroit at the deadline.
Mize has been largely impressive this season with a 3.45 ERA and a very efficient 1.10 WHIP.
While Mize appears to be settling in quite nicely with San Diego, Reds’ lefty Brandon Williamson will look to bounce back on Wednesday from what has been a nightmare season.
Williamson heads into this contest posting a dreadful 6.11 ERA and an equally bad 1.64 WHIP.
Given Williamson’s atrocious form, I anticipate Padres’ slugger Fernando Tatis Jr. having another monster performance at the plate.
The Padres’ superstar appears to have found his groove at the plate after posting the worst half-season of baseball in his career.
Since the All-Star break, Tatis Jr has been on an absolute tear, batting .302 with 12 home runs and 32 RBIs, and I fully expect his reign of dominance to continue through Wednesday afternoon’s contest.
In addition to Tatis having previously found success versus the Reds’ veteran — having gone 1-for-2 with a double and an RBI – he demolishes left-handed pitching, which should give him a definitive edge against Williamson.
Tatis carries a .482 xSLG and 92.8 mph average exit-velocity into this matchup, and should feast on Williamson’s significant vulnerability to heavy damage against right-handed power hitters like Tatis Jr.
Picks:
- Fernando Tatis Jr. Over 2.5 HRR (-102)
- Fernando Tatis Jr. 1+ Home Run (+310)
- Padres Moneyline (-149)
