The San Diego Padres host the San Francisco Giants on August 21, 2025. First pitch from PETCO Park is scheduled for 4:10 p.m. EDT; the game will be broadcast on SDPA.
Find my MLB betting preview and Giants vs Padres prediction below, as well as probable pitchers, betting trends, injury reports and more.
The Padres have won the last two games after dropping the first one and will have Dylan Cease on the mound for this series finale. Justin Verlander will get the ball for the Giants.
My Giants vs Padres Prediction
- Giants vs Padres pick: Under 8 (-130)
My Giants vs Padres best bet is Under 8 total runs in this game. Make sure to find the best odds by checking our live MLB odds page.
Giants vs Padres Odds
| Giants Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -141 | 8 -109o / -113u | +155 |
| Padres Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +114 | 8 -109o / -113u | -200 |
Giants vs Padres Projected Starting Pitchers
| RHP Justin Verlander (SF) | Stat | RHP Dylan Cease (SD) |
|---|---|---|
| 1-9 | W-L | 5-11 |
| 1.3 | fWAR (FanGraphs) | 2.6 |
| 4.23 / 4.43 | ERA / xERA | 4.61 / 3.48 |
| 3.95 / 4.57 | FIP / xFIP | 3.54 / 3.49 |
| 1.42 | WHIP | 1.31 |
| 12.6 | K-BB% | 20.2 |
| 34.9 | GB% | 35.7 |
| 107 | Stuff+ | 108 |
| 93 | Location+ | 100 |
Giants vs Padres Betting Analysis
Two of the three games of this series have produced under eight runs, with the only exception being last night's 8-1 Padres victory.
The Giants have been struggling at the plate all season long, ranking 22nd in wRC+ with a 94 rating, and this month they are down to 90 while in the same spot among all MLB teams.
The last two games have been particularly awful for San Francisco, scoring just one run in each contest.
Today, they face Dylan Cease. The Padres starter might not have dazzling numbers overall, but for this game, two of his splits are encouraging.
Cease has a 3.60 ERA at home and an even better 2.77 ERA in day games.
The Padres, on the other hand, will have to deal with Justin Verlander. Although he struggled early and clearly is no longer at his former Cy-Young-worthy level, Verlander has bounced back recently.
The veteran holds a 3.03 ERA over his last seven outings and is coming off a turn-back-the-clock start against the Rays, giving up only two hits and no runs in seven complete innings with eight strikeouts.
Our Bet Labs recommendation is to go with the under.
The Silent Sharp Unders system targets regular-season MLB games where both teams are performing well, yet the total has quietly dropped from open to close.
These are games featuring competent, winning teams with recent success, stable weather conditions, and closing totals in a common scoring range. Despite both teams showing strength, the market subtly favors the under, likely due to matchup specifics, pitching, or pace factors.
By following this soft signal —when the public eye is more focused on win streaks and not totals— this system finds value in betting against inflated scoring expectations.
Pick: Under 8 (-130, Fanatics)
Giants vs Padres Betting Trends
