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Nationals vs Rockies Prediction, Pick, MLB Odds for Wednesday, July 22

Nationals vs Rockies Prediction, Pick, MLB Odds for Wednesday, July 22 article feature image
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Photo Credit: Isaiah J. Downing-Imagn Images
Pictured: Gabriel Hughes pitches in the first inning

The Colorado Rockies host the Washington Nationals on July 22, 2026. First pitch from Coors Field is scheduled for 3:10 p.m. EDT. The game will be broadcast on NATS.

The Nationals are favored by -136 on the moneyline and by -1.5 on the run line. The Rockies are +115 on the moneyline and +1.5 on the run line. The total is set at 11.5 runs.

Find my MLB picks and Nationals vs Rockies prediction below, as well as probable pitchers, weather report, and more.


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Nationals vs Rockies Prediction

  • Nationals vs Rockies Pick: Under 11.5 (-115, DraftKings)

My Nationals vs Rockies best bet is under 11.5 total runs. Make sure to find the best odds by checking our live MLB odds page.


Nationals vs Rockies Odds

Nationals Logo
July 22, 2026
3:10 p.m. EDT
NATS
Rockies Logo
Nationals Odds
SpreadTotalMoneyline
-1.5
-130
11.5
-104o / -117u
-136
Rockies Odds
SpreadTotalMoneyline
+1.5
+109
11.5
-104o / -117u
+115
Odds via DraftKings. Get up-to-the-minute MLB odds here.
DraftKings Logo
  • Nationals vs Rockies moneyline: Nationals -136, Rockies +115
  • Nationals vs Rockies over/under: 11.5 (-104o / -117u)
  • Nationals vs Rockies spread: Nationals -1.5 (+109), Rockies +1.5 (-130)

Nationals vs Rockies Probable Pitchers

Cade CavalliStatGabriel Hughes
6-4W-L0-1
2.4fWAR (FanGraphs)0.5
3.78 / 4.14ERA / xERA3.14 / 2.74
3.21 / 3.43FIP / xFIP2.20 / 3.60
19.2K-BB%16.1
48.1GB%35.1
.340BABIP.297
102Stuff+92
98Location+104

Nationals vs Rockies MLB Betting Preview

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Nationals vs Rockies Pick, Betting Analysis

The Nationals and Rockies will square off on Wednesday afternoon to conclude a three-game set at Coors Field.

It is no surprise to see a massive 11.5 run total on Wednesday considering how much of a hitter-friendly ballpark Coors Field is.

Nationals’ right-hander Cade Cavalli will take the mound, while the Rockies will trot out rookie Gabriel Hughes, who will be making just his third career start.

Starting off, I see value in going under 11.5 with -115 juice.

In 21 starts, Cavalli has recorded a 3.78 ERA to go along with a relatively efficient 1.31 WHIP.

On the other hand, Hughes has been quite impressive too, having recorded a 3.14 ERA with a 1.12 WHIP despite such a small sample size.

Even though two of his first three starts came at Coors, Hughes has surrendered just two earned runs across over eight frames.

As if that was not impressive enough, his third start came against a loaded Dodgers lineup, pitching six innings on his way to recording his first Quality Start of his career.

Pick: Under 11.5 (-115, DraftKings)


Nationals vs Rockies Weather


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Author Profile
About the Author

Ryan graduated from Providence College in 2016 with Bachelor Degrees in Business Economics & Mathematics. It was at Providence where Ryan really first found his passion for sports betting. For a lifelong sports fan with a knack for statistical analysis, he was instantly drawn to the fundamentals of the industry, specifically how sports betting markets functioned and fluctuated. In what primarily started as a recreational hobby, Ryan began studying the ins-and-outs of sports betting markets on a daily basis. He took to Twitter (now X), where he amassed a following for writing a sports betting blog that provided statistical analysis behind his wagers. In spite of seeking employment opportunities elsewhere post graduation, Ryan continued to follow his passion for the statistical analysis of sports betting wagers, eventually deciding to pursue a career in the sports betting industry.

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