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Stephen Thompson vs Charles Radtke Prediction, Picks, Odds for UFC 334, Saturday, November 14

Stephen Thompson vs Charles Radtke Prediction, Picks, Odds for UFC 334, Saturday, November 14 article feature image
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Apr 11, 2026; Miami, Florida, UNITED STATES; Charles Radtke (red gloves) reacts after the fight against Francisco Prado (blue gloves) during UFC 327 at Kaseya Center. Mandatory Credit: Sam Navarro-Imagn Images

Check out my Stephen Thompson vs Charles Radtke prediction for UFC 334 on Saturday, November 14, along with my betting preview and breakdown.

Stephen Thompson vs Charles Radtke Odds

Thompson Odds-148
Radtke Odds+124
Over/Under2.5 (-210 / +160)
LocationMadison Square Garden, New York City
Bout Time8:45 p.m. ET
TV/StreamingParamount+
UFC 334 odds as of Saturday and via DraftKings. Bet on UFC 334 with our DraftKings promo code.

Here's my Thompson vs. Radtke pick and prediction.

Tale of the Tape

Thompson vs Radtke Pick, Prediction

Stephen "Wonderboy" Thompson enters his retirement bout at 43 years old on a three-fight losing streak (a split decision against Gabriel Bonfim, a Round 3 knockout loss to Joaquin Buckley, and a Round 2 submission loss to Shavkat Rakhmonov), after a 16-month layoff.

Charles Radtke has won two straight (a Round 3 submission over Daniel Frunza and a decision over Francisco Prado), and his only UFC losses came via knockout against Mike Malott and Carlos Prates.

Thompson is the bigger man (3" taller, 3" reach) and has outlanded 16 of his 22 UFC opponents (+1.0 strike differential per minute). He also throws more as fights extend; his third-round output averages nearly double (190%) of his first-round output. Radtke is roughly even on the feet (+0.05 per minute), with 85% of his strikes aimed at the head – and Wonderboy is notoriously difficult to track down at distance.

Radtke's path is grappling. He's controlled opponents for 51% of his UFC fight time, hasn't conceded a takedown, and landed four takedowns with more than nine minutes of control against Prado – a win that has aged well. Thompson's takedown defense has leaked for years: Gilbert Burns landed three, Belal Muhammad seven, Kevin Holland two (and could have had more if he tried), Buckley four, and Bonfim five.

The line has moved slightly toward Thompson (-141 at open, now -152 to -155), and I projected him at -143, so I'm aligned.

Instead, I see an edge on Radtke to spoil the party and win by decision (projected +359, listed +410) and, given Thompson's lack of finishes, to at least cover his point spread (+3.5, -150) with one round of effective grappling.

Still, if Radtke banks the opening round on control, Thompson's second and third rounds (+1.4 and +1.7 strike differential per minute) have been far better than Radtke's third rounds (-1.0), and I'd look for a live entry on the veteran after Round 1, even at his age.

Zerillo's Picks:

  • Charles Radtke +3.5 (-150, 0.1u), Caesars; bet to -185
  • Charles Radtke wins by Decision (+400, 0.1u); bet to +375
  • Stephen Thompson Live after Round 1   

Author Profile
About the Author

Sean graduated from the University of Miami and Hofstra University Law School, later passing the New York State Bar Exam in 2014. He shifted from a legal career to sports data and betting, joining the Action Network in 2019 after working as a baseball video scout and in financial regulatory compliance. As a senior writer and betting analyst, Sean provides MLB and MMA projections using proprietary models and contributes to various digital content and podcasts, becoming a leading expert in betting for baseball, MMA, and horse racing.

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