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Cardinals vs. Colts Odds & Betting Predictions - October 12, 2025

Cardinals at Colts

5:00 pm • FOX

Arizona Cardinals

2-2
@

Indianapolis Colts

3-1

Cardinals at Colts Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Cardinals
2-2
-1.5
+3.5-105
o47.5-105
+164
Colts
3-1
u47.5
-3.5-115
u47.5-115
-198
location pinSunday 5:00 p.m.
October 12, 2025
Lucas Oil StadiumIndianapolis

Cardinals vs. Colts Props

Prop Projections

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Cardinals vs. Colts Public Betting Percentages

Away Logo

Cardinals

Public

Home Logo

Colts

100%

Bets%

0%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Colts are 3-1 in their last 5 games.
  • Colts are 3-1 in their last 5 games against the spread
  • Colts are 1-1 in their road games against the spread
  • The totals have gone OVER in 2 of Colts' last 4 games
  • The totals have gone OVER in 1 of Colts' 2 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Colts		3-12-01-12-01-1
Cardinals		2-20-22-01-11-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Colts		2-21-11-11-11-1
Cardinals		1-31-10-21-10-2

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Colts		3-1N/AN/A2-01-1
Cardinals		2-2N/AN/A2-00-2

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 28th@LAL 20-27+3.5 LU 49.5LA +154
Sep 21st@TENW 41-20-6 WO 42.5IND -258
Sep 14thDENW 29-28+1.5 WO 43.5IND +105
Sep 7thMIAW 33-8-1.5 WU 47IND -115
Aug 23rd@CINW 41-14+2.5 WO 36.5IND +125

Cardinals vs. Colts Injury Updates

Cardinals Injuries

  • Zay Jones
    WR

    Jones is questionable with concussion

    Questionable

  • James Conner
    RB

    Conner is out with foot

    Out

  • Will Hernandez
    OL

    Hernandez is out with knee

    Out

  • Owen Pappoe
    LB

    Pappoe is questionable with quad

    Questionable

  • Dante Stills
    DE

    Stills is questionable with heel

    Questionable

Colts Injuries

  • Alec Pierce
    WR

    Pierce is questionable with concussion

    Questionable

  • Tyler Goodson
    RB

    Goodson is questionable with groin

    Questionable

See more NFL Injuries Right Arrow
Player Stats
  • passing yards
    Daniel Jones logo
    Daniel Jones
    1078
    pyds
  • passing touchdowns
    Daniel Jones logo
    Daniel Jones
    4
    ptd
  • rushing yards
    Jonathan Taylor logo
    Jonathan Taylor
    414
    ryds
  • rushing touchdowns
    Jonathan Taylor logo
    Jonathan Taylor
    3
    rtd
Depth Charts
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Starter2ND3RD4TH
QBDaniel JonesAnthony RichardsonRiley Leonard
RBJonathan TaylorTyler GoodsonDJ GiddensUlysses Bentley
WRJosh DownsAnthony GouldColeman Owen
TETyler WarrenMo Alie-CoxDrew OgletreeWill MallorySean McKeonMax Mang
LTBernhard RaimannJalen Travis
LGQuenton NelsonDalton Tucker
CTanor BortoliniDanny Pinter
RGMatt GoncalvesJosh SillsMarcellus Johnson
RTBraden SmithLuke Tenuta
LDEKwity PayeTyquan LewisJT Tuimoloau
RDELaiatu LatuSamson EbukamDurell Nchami
WLBJaylon CarliesCameron McGroneAustin Ajiake
MLBZaire FranklinJoe BachieSegun Olubi
LCBCharvarius WardXavien Howard
SSNick CrossDaniel Scott
FSCam BynumRodney ThomasTrey Washington
RCBJaylon JonesJohnathan Edwards
PRigoberto Sanchez
HRigoberto Sanchez
PRAnthony GouldJosh DownsColeman Owen
KRAnthony GouldAshton DulinTyler GoodsonDJ Giddens
LSLuke Rhodes
LWRMichael PittmanAshton DulinLaquon Treadwell
KSpencer Shrader
NBKenny MooreChris Lammons
RWRAlec PierceAdonai Mitchell
DTDeForest BucknerAdetomiwa AdebaworeTim Smith
NTGrover StewartNeville GallimoreEric Johnson
Team Stats

Passing

659
YDS
1044
87/130
Comps/Atts
87/121
5.708
YPA
8.909
6/3
TDs/INTs
4/2
13/83
Sacks/Yards
4/34

Rushing

423
Rush Yards
545
94
Attempts
121
4.5
YPC
4.504
1
TDs
7

Turnovers

Fumbles Lost
3
Interceptions
2

Efficiency

7/13 53.85%
Redzone
9/19 47.37%
20/52 0%
3rd Down
19/48 0%
4/4 0%
4th Down
6/8 0%

First Downs

69
Total
92
42
Pass
51
19
Rush
30
8
Penalty
11

Misc

/
Penalties/Yards
/
Possession

Cardinals vs. Colts Odds Comparison

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Cardinals at Colts Team Totals

MatchupOverUnder
Cardinals
2-2
N/A
N/A
Colts
3-1
N/A
N/A