Colts vs. Titans Odds & Betting Predictions - September 21, 2025

Smaller since the injuries are potentially lethal especially Sweat and entire right side of OL but can’t pass a 6.

Projection: 0.82 TDs, -233. For more, check out the Fantasy Life player projections.

Lockett has just 2 catches for 9 yards through two games, and it looks like the decline we saw late in his Seahawks career has carried into Tennessee. Rookie Chimere Dike cut into his role last week, dropping his routes-run rate to 46%. I expect that to creep back toward 50–60% this week, but the Titans clearly want to get Dike more involved, which caps Lockett’s upside. Even if his snap share rebounds, his target rate has been a huge concern. Lockett owns a 7% target rate compared to a 9% expected rate in my model. He can still catch a ball or two underneath, but he hasn’t generated yards after the catch in years, which means he’d likely need a downfield shot to threaten this line. My sim has his average at 14.5, but a median closer to 11.5 yards and 3 yards in a market like this is significantly more valuable than say a CeeDee Lamb yardage prop. Have this around a 59% chance to stay under 14.5. There will be weeks where Lockett pops up and clears a line like this, even with his role in decline. But given the usage trend, it feels like a “sell low” opportunity while the prop market is still hanging numbers in this range.

@ChrisRaybon 2 https://myaction.app/4MflgQZkKWb

Novig price

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PTP best bet #2

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Shoutout to Jacob Gibbs of CBS Sports for this crazy nugget on Daniel Jones from Week 2: His 97% first-read target rate was the highest in any game since Fantasy Points Data began charting that metric (2021). Jones now has an 84.1% first-read target rate for the season. This is point-and-shoot quarterback play at an extreme level, and it's working. Danny Dimes is 6th in EPA/play through 2 games. He's completing more than 71% of his passes and is averaging 294 passing yards per game. So who leads the Colts in first-read target rate? Of course it's Warren at 24.5%. He paces all tight ends (minimum 25 routes) in targets per route run at 29%. Warren is 3rd in yards per route run at the position (minimum 25 routes) behind only the Green Bay tight ends (Tucker Kraft and Luke Musgrave). Warren is the focal point of a red-hot passing game and should continue to see plenty of volume.

@sundaysixpack @ChrisRaybon https://myaction.app/4MflgQZkKWb

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Bet105 bit.ly/boomerh1