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Colts vs. Chargers Odds & Betting Predictions - October 19, 2025

Colts at Chargers

8:05 pm • CBS

Indianapolis Colts

3-1
@

Los Angeles Chargers

3-1

Colts at Chargers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Colts
3-1
N/A
N/A
N/A
Chargers
3-1
N/A
N/A
N/A
location pinSunday 8:05 p.m.
October 19, 2025
SoFi StadiumInglewood

Colts vs. Chargers Props

Prop Projections

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Colts vs. Chargers Public Betting Percentages

Away Logo

Colts

Public

Home Logo

Chargers

50%

Bets%

50%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Chargers are 3-1 in their last 5 games.
  • Chargers are 3-1 in their last 5 games against the spread
  • Chargers are 1-1 in their road games against the spread
  • The totals have gone OVER in 1 of Chargers' last 4 games
  • The totals have gone OVER in 0 of Chargers' 1 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Chargers		3-11-01-12-11-0
Colts		3-12-01-12-01-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Chargers		1-30-10-20-31-0
Colts		2-21-11-11-11-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Chargers		3-1N/AN/A2-11-0
Colts		3-1N/AN/A2-01-1

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 28th@NYGL 18-21-6 LU 42.5NYG -280
Sep 21stDENW 23-20-2.5 WU 45.5LAC -155
Sep 16th@LVW 20-9-3.5 WU 46.5LAC -190
Sep 6thKCW 27-21+3 WO 47.5LAC +145
Aug 24th@SFL 23-30-2.5 LO 35.5SF -152

Chargers vs. Colts Injury Updates

Chargers Injuries

  • Will Dissly
    TE

    Dissly is out with knee

    Out

  • Najee Harris
    RB

    Harris is out with achilles

    Out

Colts Injuries

  • Alec Pierce
    WR

    Pierce is questionable with concussion

    Questionable

  • Tyler Goodson
    RB

    Goodson is questionable with groin

    Questionable

See more NFL Injuries Right Arrow
Player Stats
  • passing yards
    Justin Herbert logo
    Justin Herbert
    1063
    pyds
  • passing touchdowns
    Justin Herbert logo
    Justin Herbert
    7
    ptd
  • rushing yards
    Omarion Hampton logo
    Omarion Hampton
    270
    ryds
  • rushing touchdowns
    Omarion Hampton logo
    Omarion Hampton
    2
    rtd
Depth Charts
Right Arrow
Starter2ND3RD4TH
QBJustin HerbertTrey LanceDJ Uiagalelei
RBOmarion HamptonNajee HarrisKimani VidalHassan Haskins
WRLadd McConkeyDerius DavisLuke Grimm
TEWill DisslyTyler ConklinOronde GadsdenTucker FiskThomas Yassmin
LTJoe AltJamaree Salyer
LGZion JohnsonBranson Taylor
CBradley BozemanAndre JamesJosh Kaltenberger
RGMekhi Becton
RTTrey PipkinsDavid Sharpe
RDEDa'Shawn HandJustin EboigbeScott Matlock
LCBDonte JacksonDeane Leonard
SSDerwin JamesTony JeffersonRJ Mickens
FSAlohi GilmanElijah MoldenKendall Williamson
RCBCam HartNikko ReedBenjamin St-JusteEric Rogers
PJK Scott
HJK Scott
PRDerius DavisLadd McConkeyKeAndre Lambert-Smith
KRDerius DavisHassan HaskinsKeAndre Lambert-Smith
LSJosh Harris
LWRTre' HarrisKeAndre Lambert-SmithJaQuae Jackson
RWRKeenan AllenQuentin Johnston
LILBDenzel PerrymanTroy DyeDel'Shawn PhillipsKana'i Mauga
RILBDaiyan HenleyJunior ColsonEmany JohnsonMarlowe Wax
ROLBKhalil MackBud DupreeGarmon Randolph
DTOtito OgbonniaNaquan Jones
NBTarheeb StillJa'Sir TaylorMyles Purchase
KCameron Dicker
FBScott Matlock
LOLBTuli TuipulotuKyle KennardCaleb Murphy
NTTeair TartJamaree CaldwellTeRah Edwards
Team Stats

Passing

1044
YDS
996
87/121
Comps/Atts
95/149
8.909
YPA
7.134
4/2
TDs/INTs
7/3
4/34
Sacks/Yards
12/67

Rushing

545
Rush Yards
429
121
Attempts
92
4.504
YPC
4.663
7
TDs
2

Turnovers

Fumbles Lost
2
Interceptions
3

Efficiency

9/19 47.37%
Redzone
4/11 36.36%
19/48 0%
3rd Down
23/53 0%
6/8 0%
4th Down
2/3 0%

First Downs

92
Total
83
51
Pass
49
30
Rush
24
11
Penalty
10

Misc

/
Penalties/Yards
/
Possession

Colts vs. Chargers Odds Comparison

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Colts at Chargers Team Totals

MatchupOverUnder
Colts
3-1
N/A
N/A
Chargers
3-1
N/A
N/A