Broncos vs. Chargers Odds & Betting Predictions - September 21, 2025
Broncos at Chargers
8:05 pm • CBSBroncos at Chargers Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
Broncos 7-2 | +2.5+100 | o45.5-110 | +130 | |
Chargers 0-8 | -2.5-121 | u45.5-107 | -155 | |

SoFi StadiumInglewood
Broncos vs. Chargers Expert Picks
Vegas Refund
Last 30d: 27-38-1 (-14.8u)
DEN +3-115
1.15u

Sean Zerillo
Last 30d: 131-134-2 (+2.2u)
LAC -2.5-111
0.25u
All NFL Sides + Totals bet on exchanges at significantly better odds
Tyler Shoemaker
Last 30d: 1-2-0 (-1.2u)
B.Nix o10.5 Longest Rush-120
5u
Kody Malstrom
Last 30d: 46-50-2 (-5.4u)
DEN +3-115
0.58u
Kenny Ducey
Last 30d: 1-1-0 (-0.2u)
Under 45.5-110
1u

Matthew Freedman
Last 30d: 0-0-0 (+0.0u)
Q.Johnston Anytime TD Scorer Yes+230
0.5u
Projection: +165. For more, check out the Fantasy Life player projections.
B.Nix o0.5 Int-138
0.69u
Projection: -192. For more, check out the Fantasy Life player projections.
Anthony Dabbundo
Last 30d: 41-51-0 (-5.7u)
LAC -2.5-110
1.5u
Ringer Gambling Show: https://youtu.be/Dteaxm8pxAA?si=NF2tbcTXaqTtT40G
Doug Ziefel
Last 30d: 366-310-10 (+33.9u)
Under 46.5-120
0.5u
Matt DiLeo
Last 30d: 61-41-0 (+13.2u)
Both Teams To Make 33+ Yard FG-120
0.42u
C.Dicker o1.5 FGs Made-130
0.77u
Ryan Minion
Last 30d: 236-272-8 (-26.0u)
J.Dobbins o49.5 Rush Yds-113
$1.00
Grant Neiffer
Last 30d: 14-57-1 (-4.1u)
Q.Johnston Anytime TD Scorer Yes+250
0.5u
OldSchool0909
Last 30d: 75-51-0 (+18.8u)
DEN +2.5+100
1u
Sandy Plashkes
Last 30d: 103-115-5 (-0.5u)
L.McConkey o65.5 Rec Yds-114
1.71u
The Degenerates
Last 30d: 90-83-2 (-0.7u)
DEN +130
1u
DEN +3-120
1.2u
Kyle Murray
Last 30d: 123-125-4 (+12.1u)
J.Herbert o235.5 Pass Yds-110
2u
L.McConkey o50.5 Rec Yds-110
1.1u
Lock & Cash
Last 30d: 6-8-0 (-0.8u)
LAC -2.5-110
1.36u
Austin Pendergrass
Last 30d: 88-62-0 (+11.3u)
LAC -142 (Live)
0.35u
Brandon Kravitz
Last 30d: 65-74-1 (+0.3u)
DEN +2.5+100
1u
Week 3 fade of a team we’ve probably slightly overrated off 2 wins. The Chargers beat a Chiefs team that can’t move the ball and the Raiders. Off a short week against a division rival, this should be closer to -1/-1.5.
Gilles Gallant
Last 30d: 20-65-0 (-11.3u)
Q.Johnston Anytime TD Scorer Yes+275
1u
Betting him every game at this price.
B.Nix Anytime TD Scorer Yes+460
0.5u
Greg Matherne
Last 30d: 22-19-1 (+1.1u)
DEN +3-120
0.6u
Charlie Wright
Last 30d: 0-0-0 (+0.0u)
J.Herbert o19.5 Rush Yds-140
1.4u
Herbert is off to an excellent this start this season, largely due to an adjustment in offensive mindset for the Chargers. They lead the league in pass rate over expectation through 2 games and are 5th in neutral pass rate. The ground-and-pound nature of this team under Jim Harbaugh and Greg Roman has given way to an aerial attack.
The increase in passing plays has boosted Herbert's production on the ground. He's posted 16 carries for 63 yards. After recording 7+ carries in just 2 games last season, he's done it in both games to begin this season. Herbert averaged 1.8 scrambles per game last season. He's up to 3.5 per game so far this season. Herbert has 30+ rushing yards in each game.
Denver has played man coverage at the 2nd-highest rate this season. They were 5th last season. Man coverage typically leads to more scramble opportunities, as the defensive backs are focused on their assignments and not looking at the quarterback.
The Favorites Podcast
Last 30d: 0-0-0 (+0.0u)
L.McConkey Anytime TD Scorer Yes+160
1u
@KendraMiddleton_ https://myaction.app/n9oxUJkKLWb
Mjaybrod
Last 30d: 49-71-1 (-23.5u)
DEN +3-110
1u
Colorado Kush
💰🦡 Jake
Last 30d: 93-106-0 (+19.5u)
LAC -2.5-120
1u
New Owner
Last 30d: 0-0-0 (+0.0u)
DEN +130
0.5u
DEN +2.5+103
1u
DEN +3 (Live)+100
1u
The Propfessor
Last 30d: 0-0-0 (+0.0u)
J.Herbert o20.5 Rush Yds-115
1u
Roger Goodell
Last 30d: 0-0-0 (+0.0u)
LAC -2.5-120
0.83u
Derek Carty
Last 30d: 21-22-1 (+5.6u)
N.Harris u7.5 Rush Att+112
1.12u
THE BLITZ is forecasting 6.42 rush attempts for Najee Harris compared to 8.75 rush attempts implied by sportsbooks, so I believe there is some value here. If you take the under, you’d be projected to win 69% of the time, resulting in a 45% ROI. Based on a $100 wager, the expected value here would be $45.33. Love THE BLITZ? Get all of Carty’s sports betting projections at https://evanalytics.com/products/nfl-premium-subscription?ref=inf8qq%22%3EEV Analytics!
Kendra Middleton
Last 30d: 14-20-0 (-2.7u)
L.McConkey Anytime TD Scorer Yes+160
1u
Broncos vs. Chargers Previews & Analysis
Broncos vs. Chargers Props
Prop Projections
There are no prop projections found for the selected slate. Please check back later.
Prop Odds Comparison
Line Movement Tracker
Broncos vs. Chargers Public Betting Percentages
Betting Trends
- Chargers are 0-5 in their last 5 games.
- Chargers are 0-4 in their last 5 games against the spread
- Chargers are 0-3 in their road games against the spread
- The totals have gone OVER in 2 of Chargers' last 5 games
- The totals have gone OVER in 1 of Chargers' 4 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Broncos vs. Chargers Injury Updates

Broncos Injuries
- Tyler BadieRB
Badie is out with thumb
Out
- RJ HarveyRB
Harvey is out with knee
Out

Chargers Injuries
- David NjokuTE
Njoku is questionable with leg
Questionable
- Alec IngoldFB
Ingold is out with shoulder
Out
- Justin HerbertQB
Herbert is questionable with finger
Questionable
- Ladd McConkeyWR
McConkey is questionable with back
Questionable
- Brenen ThompsonWR
Thompson is out with unknown
Out
Team Stats
Broncos vs. Chargers Odds Comparison
Could not load odds
Broncos at Chargers Team Totals
MatchupOverUnder | ||
|---|---|---|
Broncos 7-2 | N/A | N/A |
Chargers 0-8 | N/A | N/A |




