Rams vs. 49ers Odds & Betting Predictions - November 9, 2025

Rams at 49ers

9:25 pm • FOX
@

Rams at 49ers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Rams
6-2
+1.5
-5.5-115
o49.5-110
-250
49ers
6-3
u46.5
+5.5-105
u49.5-110
+205
location pinSunday 9:25 p.m.
November 09, 2025
Levi's StadiumSanta Clara
thermometer image76°Fahrenheit
rain image0%Rain
wind image4Wind
Rams vs. 49ers Expert Picks
Babs .
Babs .
Last 30d: 102-129-3 (-26.3u)
J.Whittington u1.5 Recs+130
1u
YBK Picks.com
Last 30d: 54-39-1 (+29.0u)
LA -5.5-105
2u
Moneyline Hacks
Moneyline Hacks
Last 30d: 133-144-2 (+36.9u)
K.Williams Anytime TD Scorer Yes+100
1u
🚨Free analysis & VIP Picks can be found on our Discord. Link: https://discord.gg/JrzjtqdVfA 🎙️Fade the Noise PODCAST - Subscribe!✅ https://www.youtube.com/@FadetheNoise 💎FREE TRIAL!!➡️ https://fas.st/t/EbWTQK7M (COPY & PASTE LINK) 🔥 50% OFF 1-MONTH VIP!! 🔥 Get full access to every bet, model, and tools from the Moneyline Hacks team. ⬇️⬇️ 💰 PROMO CODE: ValueHacks50 🌐 MoneylineHacks.com
Sandy Plashkes
Sandy Plashkes
Last 30d: 104-122-3 (-18.4u)
SF +6-110
1.1u
RocketPlays
RocketPlays
Last 30d: 45-92-0 (+9.4u)
B.Corum o25.5 Rush Yds-135
1.35u
Allan Lem
Allan Lem
Last 30d: 163-112-3 (+15.6u)
C.McCaffrey u13.5 Longest Rush-115
0.58u
Tailing @nick_giffen
Nick Giffen
Nick Giffen
Last 30d: 42-57-0 (+5.2u)
C.McCaffrey u13.5 Longest Rush-115
1.15u
Christian McCaffrey Longest Rush under 13.5 yards (-115 Bet365, 120 DK/MGM/ESPN) Since McCaffrey returned from injury in 2024, he has just 6 carries out of 194 carries from at least 14 yards from the end zone that have cleared 13.5 yards for a paltry 3.1% compared to the NFL average of 5.5% (removing QB scrambles). This year, CMC has cleared this in just 3 of 9 games, with those coming against the Arizona Cardinals who rank ninth worst in explosive run rate allowed, the Atlanta Falcons in which is took him 24 carries to get a longest run of 15 yards, and the New York Giants who rank third worst in explosive run rate allowed where he cleared his 15.5 longest rush line by the hook on 28 carries (and I gave out over last week in that game). But now he faces a Rams defense that is second-best in preventing explosive runs. Earlier this year when these two teams played, McCaffrey's longest run was just 8 yards on 22 carries. This year, in three games against top-five defenses in preventing explosive runs, McCaffrey has a longest run of just 13 yards on 61 carries. Additionally, the 49ers run zone concept runs with CMC 65% of the time, which is what the Rams defense has been better at stopping (3.86 ypc, 41.8% success rate allowed compared to 4.38 and 51.8% vs. man/gap concept runs). In my most generous projections where I overprojected his carries, fraction of carries from at least 14 yards out, and use generous distributions for his carry length and LA's allowed carry length, I'm still getting he stays under 13.5 almost 63% of the time.
Brandon Anderson
Brandon Anderson
Last 30d: 52-85-0 (+17.8u)
P.Nacua 100+ Receiving Yards Yes+116
0.4u
We took Rams -3 on the Hot Read as our first pick Sunday night. We've got some good value there now that the line is up to -4.5 and rising. There's not much value left on a Rams spread now, but we can still invest in this elite offense against what might be the worst defense in the league. San Francisco has been demolished by injuries. The 49ers rank 31st in EPA per play against the middle of the field too, so Puka Nacua should eat, and Matthew Stafford had his biggest game of the season in the first meeting. Usually with Nacua, I just want receptions, but books are steering us away by pricing 8+ receptions at -130 juiced. But when Nacua does catch at least eight passes, as he's done 15 times in his career, he also racks up yardage — at least 85 yards in all but one game, with 100+ yards in 11 of 15 (73%). The 49ers allow the seventh-most yards to opposing WRs. Nacua had 10 catches for 85 yards in the first meeting this year, and the similarly-styled Jaxon Smith-Njigba had 9/124. The 49ers also rank bottom 10 in EPA per play against deep passes while the Rams rank top four passing deep and go there often, leaving the possibility of a big chunk play. Play Nacua 100+ receiving yards at +116 (DraftKings). He averages 126 YPG in his 15 games with 8+ catches, and he topped 150 yards in 40% of them, so play the yardage escalator at 120 yards for +223 and 150+ at +600 (both at DraftKings).
P.Nacua o119.5 Rec Yds+223
0.25u
We took Rams -3 on the Hot Read as our first pick Sunday night. We've got some good value there now that the line is up to -4.5 and rising. There's not much value left on a Rams spread now, but we can still invest in this elite offense against what might be the worst defense in the league. San Francisco has been demolished by injuries. The 49ers rank 31st in EPA per play against the middle of the field too, so Puka Nacua should eat, and Matthew Stafford had his biggest game of the season in the first meeting. Usually with Nacua, I just want receptions, but books are steering us away by pricing 8+ receptions at -130 juiced. But when Nacua does catch at least eight passes, as he's done 15 times in his career, he also racks up yardage — at least 85 yards in all but one game, with 100+ yards in 11 of 15 (73%). The 49ers allow the seventh-most yards to opposing WRs. Nacua had 10 catches for 85 yards in the first meeting this year, and the similarly-styled Jaxon Smith-Njigba had 9/124. The 49ers also rank bottom 10 in EPA per play against deep passes while the Rams rank top four passing deep and go there often, leaving the possibility of a big chunk play. Play Nacua 100+ receiving yards at +116 (DraftKings). He averages 126 YPG in his 15 games with 8+ catches, and he topped 150 yards in 40% of them, so play the yardage escalator at 120 yards for +223 and 150+ at +600 (both at DraftKings).
P.Nacua 150+ Receiving Yards Yes+600
0.1u
We took Rams -3 on the Hot Read as our first pick Sunday night. We've got some good value there now that the line is up to -4.5 and rising. There's not much value left on a Rams spread now, but we can still invest in this elite offense against what might be the worst defense in the league. San Francisco has been demolished by injuries. The 49ers rank 31st in EPA per play against the middle of the field too, so Puka Nacua should eat, and Matthew Stafford had his biggest game of the season in the first meeting. Usually with Nacua, I just want receptions, but books are steering us away by pricing 8+ receptions at -130 juiced. But when Nacua does catch at least eight passes, as he's done 15 times in his career, he also racks up yardage — at least 85 yards in all but one game, with 100+ yards in 11 of 15 (73%). The 49ers allow the seventh-most yards to opposing WRs. Nacua had 10 catches for 85 yards in the first meeting this year, and the similarly-styled Jaxon Smith-Njigba had 9/124. The 49ers also rank bottom 10 in EPA per play against deep passes while the Rams rank top four passing deep and go there often, leaving the possibility of a big chunk play. Play Nacua 100+ receiving yards at +116 (DraftKings). He averages 126 YPG in his 15 games with 8+ catches, and he topped 150 yards in 40% of them, so play the yardage escalator at 120 yards for +223 and 150+ at +600 (both at DraftKings).
Action Pod NFL Picks
Action Pod NFL Picks
Last 30d: 68-103-0 (+9.0u)
P.Nacua 100+ Receiving Yards Yes+116
0.86u
P.Nacua 150+ Receiving Yards Yes+600
0.17u
P.Nacua o119.5 Rec Yds+223
0.45u
TAN Pod Touchdown Show
TAN Pod Touchdown Show
Last 30d: 27-91-2 (-4.7u)
K.Williams Anytime TD Scorer Yes+100
0.5u
J.Jennings Anytime TD Scorer Yes+250
0.5u
Grant Neiffer
Grant Neiffer
Last 30d: 44-83-2 (+10.0u)
K.Williams Anytime TD Scorer Yes+110
0.5u
Boomer Betz
Boomer Betz
Last 30d: 211-190-10 (+23.9u)
G.Kittle o45.5 Rec Yds-115
1.15u
K.Williams o2.5 Recs+140
1u
@Locko_Rocco
Moneyline Hacks
Moneyline Hacks
Last 30d: 133-144-2 (+36.9u)
Under 49.5-110
1u
🚨Free analysis & VIP Picks can be found on our Discord. Link: https://discord.gg/JrzjtqdVfA 🎙️Fade the Noise PODCAST - Subscribe!✅ https://www.youtube.com/@FadetheNoise 💎$100K Challenge💎 https://www.playerprofit.com/ 10% OFF Any Bankroll - Promo Code: HACKS 🔥 50% OFF 1-MONTH VIP!! 🔥 Get full access to every bet, model, and tools from the Moneyline Hacks team. ⬇️⬇️ 💰 PROMO CODE: ValueHacks50 🌐 MoneylineHacks.com
Kenny Ducey
Kenny Ducey
Last 30d: 17-16-0 (-0.8u)
LA -4.5-110
1.1u
Action Pod NFL Picks
Action Pod NFL Picks
Last 30d: 68-103-0 (+9.0u)
Over 49.5-110
1u
@Stuckey2 Favorite Total https://myaction.app/25SlQ7HP4Xb
SF +4.5-110
1u
Sunday Six Pack
Sunday Six Pack
Last 30d: 13-11-0 (+0.8u)
SF +4.5-110
1.1u
💰🦡 Jake
💰🦡 Jake
Last 30d: 103-110-10 (+1.0u)
LA -4-115
1.73u
LA -4-110
1.1u
Chris Raybon
Chris Raybon
Last 30d: 12-19-1 (-7.9u)
SF +4.5+100
1u
Action Pod NFL Picks
Action Pod NFL Picks
Last 30d: 68-103-0 (+9.0u)
LA -3-105
1u
@wheatonbrando Week 10 Hot Read https://myaction.app/pW5ZLhuMZXb
Brandon Anderson
Brandon Anderson
Last 30d: 52-85-0 (+17.8u)
LA -3-110
1.5u
🔥 Week 10 Hot Read 🔥
Top Shelf Action 🥃
Top Shelf Action 🥃
Last 30d: 229-211-8 (+1.6u)
LA -3+108
0.9u
4% ev play to +100

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Rams vs. 49ers Props

Prop Projections

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Prop Odds Comparison

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Line Movement Tracker

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Rams vs. 49ers Public Betting Percentages

Away Logo

Rams

Public

50%

Bets%

50%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
49ers
5-41-24-23-22-2
Rams
6-23-12-16-10-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
49ers
5-41-24-23-22-2
Rams
3-51-32-12-51-0

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
49ers
6-3N/AN/A4-12-2
Rams
6-2N/AN/A6-10-1

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Nov 2nd@NYGW 34-24-2.5 WO 47.5SF -146
Oct 26th@HOUL 15-26+3 LU 41.5HOU +130
Oct 20thATLW 20-10-0.5 WU 46.5SF -105
Oct 12th@TBL 19-30+3.5 LO 47TB +160
Oct 3rd@LAW 26-23+7.5 WO 43.5SF +340

Rams vs. 49ers Injury Updates

Rams Injuries

  • Tutu Atwell
    WR

    Atwell is out with hamstring

    Out

  • Jordan Whittington
    WR

    Whittington is questionable with back

    Questionable

49ers Injuries

  • Brandon Aiyuk
    WR

    Aiyuk is out with knee

    Out

  • Brock Purdy
    QB

    Purdy is out with toe

    Out

  • Ricky Pearsall
    WR

    Pearsall is out with knee

    Out

  • Jacob Cowing
    WR

    Cowing is out with hamstring

    Out

  • Jordan James
    RB

    James is doubtful with finger

    Doubtful

Player Stats
  • passing yards
    Mac Jones logo
    Mac Jones
    1832
    pyds
  • passing touchdowns
    Mac Jones logo
    Mac Jones
    10
    ptd
  • rushing yards
    Christian McCaffrey logo
    Christian McCaffrey
    596
    ryds
  • rushing touchdowns
    Christian McCaffrey logo
    Christian McCaffrey
    4
    rtd
Depth Charts
Right Arrow
Starter2ND3RD4TH
QBBrock PurdyMac JonesKurtis Rourke
RBChristian McCaffreyIsaac GuerendoJordan James
WRJauan JenningsJacob CowingSkyy MooreJunior Bergen
TEGeorge KittleLuke FarrellJake TongesBrayden Willis
LTTrent WilliamsSpencer Burford
LGBen BartchNick Zakelj
CJake BrendelMatt HennessyDrake Nugent
RGDominick PuniConnor Colby
RTColton McKivitzAusten Pleasants
LDENick BosaYetur Gross-MatosRobert BealWilliam Bradley-King
RDEMykel WilliamsBryce HuffSam Okuayinonu
WLBDee WintersNick MartinJalen Graham
MLBFred WarnerLuke GiffordTatum BethuneCurtis Robinson
LCBRenardo GreenJakob Robinson
SSJi'Ayir BrownMalik MustaphaDerrick Canteen
FSJason PinnockMarques SigleSiran Neal
RCBDeommodore LenoirDarrell Luter
PThomas Morstead
PRJacob CowingJunior BergenJordan WatkinsRicky Pearsall
KRIsaac GuerendoJunior Bergen
LSJon Weeks
NBUpton StoutChase Lucas
LWRBrandon AiyukRussell GageMalik Turner
NTJordan ElliottC.J. WestKalia Davis
FBKyle Juszczyk
RWRRicky PearsallJordan WatkinsMalik Turner
DTKevin GivensAlfred CollinsSebastian ValdezEvan Anderson
Team Stats

Passing

2064
YDS
2295
184/275
Comps/Atts
216/323
7.807
YPA
7.486
21/2
TDs/INTs
14/9
13/83
Sacks/Yards
18/123

Rushing

895
Rush Yards
874
218
Attempts
249
4.106
YPC
3.51
5
TDs
5

Turnovers

Fumbles Lost
2
Interceptions
9

Efficiency

21/35 60%
Redzone
17/30 56.67%
36/91 0%
3rd Down
57/121 0%
10/14 0%
4th Down
7/12 0%

First Downs

184
Total
192
106
Pass
123
55
Rush
55
23
Penalty
14
/
Penalties/Yards
/
Possession

Rams vs. 49ers Odds Comparison

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Rams at 49ers Team Totals

MatchupOverUnder
Rams
6-2
N/A
N/A
49ers
6-3
N/A
N/A