San Francisco 49ers NFL Draft Picks, Needs & First Round Betting Odds

San Francisco 49ers NFL Draft Picks, Needs & First Round Betting Odds article feature image
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Pictured: 49ers Head Coach Kyle Shanahan. (Photo by Thearon W. Henderson/Getty Images)

  • The 2021 NFL Draft begins Thursday, April 29 at 7 p.m. ET, and the San Francisco 49ers hold the 3rd overall pick in the First Round.
  • Below, you’ll find a full breakdown of the 49ers’ 2021 NFL Draft picks, first round betting odds, plus analysis for San Francisco’s team needs by position.

San Francisco 49ers Draft Picks

Picks (9)
3
43
102
117
155
172
180
194
230

49ers Draft Odds

Position of Second Pick Odds
Offense -104
Defense -121
Odds as of late Wednesday and via DraftKings.
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49ers Draft Needs

by Samantha Previte

  • QB: Jimmy Garoppolo may be a serviceable quarterback, but he isn’t the franchise signal-caller the 49ers may have hoped for. San Francisco made the move up to pick No. 3 via a trade with Miami and are poised to select a signal-caller — likely either Mac Jones, Trey Lance or Justin Fields — with that pick.
  • CB/S: The 49ers’ pass defense was strong last season and ranked fourth in passing yards allowed per game (207.9). They lost two cornerbacks this offseason, however, in Ahkello Witherspoon and Richard Sherman who will need to be replaced.
  • OL: San Francisco was below average in pass protection and ranked 21st in sacks allowed per game (2.4). They should invest in a lineman to protect whichever QB they select at No. 3.
  • WR: With Kendrick Bourne gone, the 49ers are rather lean at the receiver position after Deebo Samuel — who missed 9 games last year — and sophomore Brandon Aiyuk.

by Chris Raybon

  • QB: Garoppolo is 22-8 as the 49ers’ starter but has missed 23 starts over the past three seasons. Trading up to No. 3 overall shows the 49ers are serious about addressing this need.
  • RT: Mike McGlinchey has been elite as run blocker but below-average as pass blocker throughout his career. Adding a viable replacement would give the team flexibility to move him to guard and/or decline his fifth-year option.
  • CB: The 49ers lost Witherspoon, who graded out fifth-best among 136 qualified corners, and Sherman, who ranked 38th. In Jason Verrett, Emmanuel Moseley, K’Waun Williams and Dontae Johnson, the 49ers still have enough to field an above-average unit, but they need insurance. Verrett was a top-10 corner last season but it was the first time he played more than four games since 2015. Moseley was 37th in 2019 but 79th last year. Williams has been above-average every year of his career, but played a career-low eight games last year and will be 30 this year. Johnson graded out above average, but it was the time he’d done so since 2015.
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