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NFL Odds, Picks, Predictions: Late Slate for Week 10 Covered

NFL Odds, Picks, Predictions: Late Slate for Week 10 Covered article feature image
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Getty Images. Pictured: Dak Prescott.

  • We have bettors covered for Week 10 in the NFL.
  • Use the menu below to find the late slate, including odds and links to full breakdowns.

Week 10 NFL Odds & Picks

 

Click on a matchup to skip to that matchup preview and pick.
Jaguars vs. Chiefs
1 p.m. ET
Texans vs. Giants
1 p.m. ET
Vikings vs. Bills
1 p.m. ET
Lions vs. Bears
1 p.m. ET
Saints vs. Steelers
1 p.m. ET
Browns vs. Dolphins
1 p.m. ET
Broncos vs. Titans
1 p.m. ET
Colts vs. Raiders
4:05 p.m. ET
Cowboys vs. Packers
4:25 p.m. ET
Cardinals vs. Rams
4:25 p.m. ET
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Jaguars Odds
Spread Total Moneyline
+9.5
-110
50.5
-114o / -106u
+370
Chiefs Odds
Spread Total Moneyline
-9.5
-110
50.5
-114o / -106u
-480
Odds via FanDuel. Get up-to-the-minute NFL odds here.

John LanFranca: Can Jacksonville’s defense get enough stops in this contest? It’s a fair question.

Oddly, all three 40-point performances by the Chiefs this season have come on the road. Kansas City has averaged only 25.2 points per game at home this season, which has translated to teams like the Titans, Raiders and Chargers playing them tightly.

Patrick Mahomes is 14-19-1 (42.4%) against the spread (ATS) in his career at Arrowhead. In all games that the Mahomes-led Chiefs have been favored by 7 points or greater, K.C. is 12-17-1 (41.4%) ATS. The last time the Chiefs beat a team by more than one-possession season in Kansas City (excluding the Steelers led by a watered-down Ben Roethlisberger) was Dec. 12, 2021, against the Raiders. 

The Jaguars have six losses this season, but none of them were by more than one possession. Since the beginning of 2019, in games where greater than 60% of the public tickets were on the Chiefs at home, they have covered only twice in ten opportunities. This is a very difficult spot for the Chiefs when taking into consideration they are coming off a primetime game in which their offense played 91 snaps. Not to mention next week they have another primetime game against their new-age AFC rival, the Chargers.

While I am expecting a lot of points in this game, the safest bet to make is Jaguars plus the points. The sportsbooks have no choice but to open this number at an inflated price behind the top scoring offense in football. I will gladly side with the underdog to comfortably keep pace.

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Read the full Jaguars vs. Chiefs preview or return to the table of contents

Texans Odds
Spread Total Moneyline
-115
41.5
-105o / -115u
+188
Giants Odds
Spread Total Moneyline
-105
41.5
-105o / -115u
-225
Odds via FanDuel. Get up-to-the-minute NFL odds here.

Dylan Wilkerson: If we rewind to Week 8, I gave out Derrick Henry over 99.5 rushing yards. He soared over that total in the first half! The week before, we took Josh Jacobs over 84.5 rushing yards. He ended up with 143.

This week, I am going back to the well. We are going to fade this Texans run defense and bet on Barkley to have another big day.

You can get Barkley’s rushing total at 92.5 at BetRivers. Check out the Action Labs Player Props tool for his up-to-date totals across all sportsbooks, as well.

Pick: Saquon Barkley Over 92.5 Rush Yards | Bet to 100.5

Read the full Texans vs. Giants preview or return to the table of contents

Vikings Odds
Spread Total Moneyline
+6.5
-106
46.5
-115o / -105u
+240
Bills Odds
Spread Total Moneyline
-6.5
-114
46.5
-115o / -105u
-295
Odds via FanDuel. Get up-to-the-minute NFL odds here.

Cody Goggin: The total for this game is already too low, and the Vikings team total also dropping is just a derivative of this game line. If anything, Minnesota’s implied total should probably increase as they should have more drives and chances to score.

The Vikings offense is overall a fairly average unit, but it does have some advantages over Buffalo in the run game. Also, the Bills’ injuries will comprise the back end of this defense, giving Cousins and Justin Jefferson a chance to have success.

In addition to the injury report, I would also recommend monitoring the weather since there is a chance for some wintry mix of rain and snow that could affect this total. At 19.5, I would take the Vikings team total over without hesitation. I would take this up to 23.5 points.

Pick: Vikings Team Total Over 19.5

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Read the full Vikings vs. Bills preview or return to the table of contents

Lions vs.

Bears

Lions Odds
Spread Total Moneyline
+3
-115
48.5
-110o / -110u
+128
Bears Odds
Spread Total Moneyline
-3
-105
48.5
-110o / -110u
-152
Odds via FanDuel. Get up-to-the-minute NFL odds here.

Landon Silinsky: I expect there to be quite a bit of scoring in this game. The Bears offense seems to be really coming on as Fields continues to progress.

The Lions will have absolutely no answer for Fields’ dual-threat ability, and we should see some more Chase Claypool this week after he saw just 26 snaps last week in his first game with the Bears.

For the Lions, their two stud playmakers – D’Andre Swift and Amon-Ra St. Brown – are both healthy and ready to go, which should make life much easier for Goff. Having Swift out there as a security blanket to dump off to when your first reads are not there is incredibly valuable for this offense.

Just as bad as Detroit’s defense has been, its offense has been almost as good. The Lions rank 11th in the NFL in points scored, and the way they play elicits a ton of shootouts.

This game has a total of 48.5, which is the second highest on the Week 10 slate behind Kansas City vs. Jacksonville. I will take the over here, as I just don’t see how either defense plays well in this spot. The Lions are coming off an emotional win against a division rival and now are going on the road to face this red-hot Bears offense.

Good luck.

Pick: Over 48.5 | Bet to 49

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Read the full Lions vs. Bears preview or return to the table of contents

Saints Odds
Spread Total Moneyline
-1
-108
39.5
-114o / -106u
-108
Steelers Odds
Spread Total Moneyline
+1
-112
39.5
-114o / -106u
-108
Odds via FanDuel. Get up-to-the-minute NFL odds here.

Phillip Kall: As we enter the second half of the season, we will transition to borderline playoff teams playing with more on the line and struggling teams developing young players. Despite only a slight disparity in record, these teams fall into opposite buckets. 

The Saints are still in a tight, albeit lackluster, playoff race. With each game being more and more important. The Steelers are pretty much out of the playoff picture and just trying to figure out what will work next year.

This means the Steelers will be experimenting on offense and trying to gain as much insight into Pickett as they can, while the Saints will be focused on doing whatever it takes to win. 

Yes, there is the worry that Watt and the Steelers’ D will capitalize on the Saints’ turnover-prone nature. But, Pittsburgh’s porous offense gives little threat of turning New Orleans’ mistakes into touchdowns.

Pittsburgh has won just one game with Pickett as the starter, which was Week 6 against Tampa Bay. However, Mitch Trubisky was the quarterback in that game late making the big third-down conversions. Until proven otherwise, I am not going to trust the Steelers to do much offensively. And I will hope the Saints don’t shoot themselves in the foot too badly.

Back the Saints to make the NFC South a neck-and-neck race for first to eight wins.

Pick: Saints -1.5 | Bet to -2.5

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Read the full Saints vs. Steelers preview or return to the table of contents

Browns Odds
Spread Total Moneyline
+3.5
-115
49.5
-105o / -115u
+152
Dolphins Odds
Spread Total Moneyline
-3.5
-105
49.5
-105o / -115u
-180
Odds via FanDuel. Get up-to-the-minute NFL odds here.

Blake Krass: I don’t doubt the Dolphins will hit a few explosive plays, but I think, with the extra prep time, the Browns will be able to limit those and contain this Dolphins offense.

The Browns should be able to exploit this Dolphins secondary, and once they do and the Dolphins are forced to respect the passing game, they can churn Chubb and Hunt in the second half and wear the Dolphins’ defense down.
I think this game could easily come down to a field goal on either side.

Other than one outlier, the Browns’ losses this season have come by one, three, two and three. Other than Week 1, every Dolphins win has been by one score.

That makes the Browns getting more a field goal or more a great number to grab.

What is QuickSlip?

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Read the full Browns vs. Dolphins preview or return to the table of contents

Broncos Odds
Spread Total Moneyline
+2.5
-110
39.5
-105o / -115u
+114
Titans Odds
Spread Total Moneyline
-2.5
-110
38.5
-105o / -115u
-134
Odds via FanDuel. Get up-to-the-minute NFL odds here.

Anthony Dabbundo: There are 45 quarterbacks with at least 40 plays logged this season, and Malik Willis is 44th in efficiency. Tannehill is 17th, so he’s a clear upgrade for the Titans passing offense.

But in this matchup against an elite Denver secondary, it’s hard to see the Titans doing much to sustain offense through the air. It’s likely to be Derrick Henry or bust and it’s not as if the Titans have been elite at running the ball this season.

The Titans are a middle of the pack running team and Denver’s run defense has been slightly above average this season. If you look at our Action Network Luck Ratings, the Titans are the fourth-luckiest team in the league. Close wins, outperforming underlying numbers and some good breaks have inflated their record.

NFL fans and media have mocked Wilson and the Broncos, but they rank 28th in luck. They’ve had a ton of close bounces go against them this year. This is a great spot for Denver, coming off a bye against a potentially exhausted Tennessee defense.

This game should be closer to a pick’em with Tannehill in. If he’s out, the Broncos should be favored. Denver is a great teaser option because you can tease them through three and seven, but I’m betting the spread.

What is QuickSlip?

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Read the full Broncos vs. Titans preview or return to the table of contents

Colts Odds
Spread Total Moneyline
+4.5
-114
41.5
-110o / -110u
+166
Raiders Odds
Spread Total Moneyline
-4.5
-106
41.5
-110o / -110u
-195
Odds via FanDuel. Get up-to-the-minute NFL odds here.

The Great Foosini: Looking at similar opponents and home/road trends for each team, we see the Colts vastly underperform against the market, especially on the road, and Las Vegas overperform at home.

As I’ve stated above, this is not a game I will be keen on watching, but we can surely expect a ton of headlines to come out of it. I’m going to assume that we have little difference with Saturday at the helm (some people like a new coach to inject life, this just does not seem like the team for that), and that Ehlinger remains, well, Ehlinger.

Again, given the market valuations of each team, and their relative efficiencies to date, I have the spread projected at 5.3, so I’m showing an edge to the Raiders here at home. This aligns with the 1-2 point favorite on a neutral field logic I gave above.

Beyond having a good number, Las Vegas performs well at home, and is coming back off of two tough losses. I expect Carr to actually produce this weekend, and McDaniels needs to put some wins on the board to keep his job. Let’s take the Raiders -4.5.

What is QuickSlip?

QuickSlip is an Action Network feature that allows users to automatically load their bet slip at FanDuel Sportsbook.


Read the full Colts vs. Raiders preview or return to the table of contents

Cowboys Odds
Spread Total Moneyline
-3.5
-115
44.5
-110o / -110u
-205
Packers Odds
Spread Total Moneyline
+3.5
-105
44.5
-110o / -110u
+172
Odds via FanDuel. Get up-to-the-minute NFL odds here.

Anthony Dabbundo: The Cowboys are clearly the better team, but we’ve reached the bottom of the market on Green Bay with this line. The summer lookahead line was Green Bay -3.5 and now the Packers are catching more than a field goal at home.

Based on our Action Network luck rankings, Dallas has been the third most fortunate team in the NFL. A lot of that was built up with Cooper Rush in at quarterback, but the Cowboys have had a lot of bounces go their way to have won all but one of his starts.

Green Bay has been the least fortunate team in the league. A lot of that stems from last week’s loss to Detroit with all of the red-zone turnovers. You also have to consider the late collapse to the Giants and the close loss to the Commanders.

Dallas is the better team, but Green Bay is still average enough to the point where +4.5 at home is a good bet. I’d bet them at +4 or better.

What is QuickSlip?

QuickSlip is an Action Network feature that allows users to automatically pre-load their bet slip at FanDuel Sportsbook.


Read the full Cowboys vs. Packers preview or return to the table of contents

Cardinals Odds
Spread Total Moneyline
+3
-112
40.5
-114o / -106u
+136
Rams Odds
Spread Total Moneyline
-3
-108
40.5
-114o / -106u
-162
Odds via FanDuel. Get up-to-the-minute NFL odds here.

Ricky Henne: I’m with the public on this one.

Arizona road unders are 3-1 on the year while Los Angeles home unders are 2-3. That trend should continue. The teams combined for just 32 points in the Rams’ 20-12 win in Week 3, and that was with two healthy starting quarterbacks.

The Rams struggle to put up points even with Stafford under center. And if he can’t go? Well, Wolford doesn’t exactly strike fear in the hearts of opposing defenses.

Meanwhile, the Rams are only the second top 10 overall defense the Cardinals have played all season. Throw in the fact that Los Angeles has had Murray’s number over the years and the under is the clear play.

That being said, pay close attention to each quarterback’s status leading up to kickoff. If both suit up, consider playing the under up to 43.5, which was the number before the injuries became public.

What is QuickSlip?

QuickSlip is an Action Network feature that allows users to automatically pre-load their bet slip at FanDuel Sportsbook.


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