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49ers vs Falcons Prediction, Pick, Odds for NFL Week 7

49ers vs Falcons Prediction, Pick, Odds for NFL Week 7 article feature image
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Reuters/Imagn. Pictured: Brock Purdy, Bijan Robinson.

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The undefeated San Francisco 49ers (6-0) take on the skidding Atlanta Falcons (2-4) in NFL Week 7 action today. Kickoff is set for 1:00 p.m. ET from Mercedes-Benz Stadium in Atlanta, Ga. The game will broadcast live on FOX.

The 49ers are 2.5-point favorites over the Falcons on the spread, with the over/under set at 49.5. San Francisco is a -148 moneyline favorite and Atlanta is a +126 underdog.

Let's get into my 49ers vs Falcons predictions for today's NFC Week 7 clash.


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49ers vs Falcons Prediction

My 49ers vs. Falcons best bet is Atlanta to cover the spread (+3), with the best price currently available at FanDuel. Make sure to find the best odds by checking our live NFL odds page.

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49ers vs Falcons Odds

49ers Logo
Sunday, Oct. 25
1 p.m. ET
FOX
Falcons Logo
49ers Odds
SpreadTotalMoneyline
-2.5
-120
49.5
-115o / -105u
-148
Falcons Odds
SpreadTotalMoneyline
+2.5
-102
49.5
-115o / -105u
+126
Odds via FanDuel. Get up-to-the-minute NFL odds here.
FanDuel Logo
  • 49ers vs Falcons Moneyline: 49ers -148, Falcons +126
  • 49ers vs Falcons Total: 49.5
  • 49ers vs Falcons Spread: 49ers -2.5 (-120), Falcons +2.5 (-102)

49ers vs Falcons NFL Week 7 Preview

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San Francisco 49ers Betting Preview: Injury Bug Bites

The 49ers are sitting at an unblemished 5-0, but we are likely at the peak of their market value right now.

Brock Purdy has been incredible and is currently the betting favorite for MVP, but you have to look at the massive schedule assistance this team has received.

The 49ers opened the year against a jet-lagged Rams team in Australia, followed by a string of home games against broken offenses like the Broncos and Dolphins. San Francisco's only true road test was a highly fluky win in Seattle.

Now, the injury bug is biting them. The 49ers are likely going to be without Nick Bosa and Kyle Juszczyk, but the biggest blow is Mike Evans., who suffered an Achilles injury on Monday Night Football.

The offensive splits for San Francisco with and without Evans are night and day. The veteran averages an elite 0.33 EPA per route run — the highest in the Next Gen Stats era — and serves as Purdy's ultimate safety valve over the middle of the field on critical third downs.

Additionally, there is a fascinating historical trend here: Purdy is just 3-6 against the spread (ATS) when playing in a domed stadium. Clay Martin is officiating this game, a referee whose crews have seen favorites go an abysmal 42-61 ATS.


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Atlanta Falcons Betting Preview: Desperation Spot

The Falcons are returning home after suffering back-to-back home losses, making this a desperation spot for a team that was flying high just a couple weeks ago.

Yes, the Falcons were destroyed by the Bears last week, but the box score was misleading. Atlanta went 0-for-3 on fourth downs, fumbled a kick return, and muffed a punt inside its own 10-yard line.

You simply cannot overcome that kind of variance.

Offensively, Michael Penix Jr. changes the entire dynamic of this team.

If the Falcons can stay on script and avoid falling behind early, they have the ultimate weapon in Bijan Robinson to relentlessly attack a 49ers defense that is suddenly missing Dre Greenlaw and struggling to stop the run.


49ers vs Falcons Prediction, Betting Analysis

This is the ultimate "amateur psychologist" spot.

You have an undefeated 49ers team dealing with major structural injuries to their offense, traveling across the country on a short week to face a desperate Falcons squad looking to avoid three straight home losses before a big divisional game against the Buccaneers in Week 8.

I expect Michael Penix Jr. and Bijan Robinson to exploit San Francisco's injuries, control the clock, and keep this game highly competitive.

Fade the overpriced 49ers here.

Pick: Falcons +3 (-120)


49ers vs Falcons Betting Trends

49ers Trends

  • Kyle Shanahan is 0-4 ATS with Clay Martin officiating over the last five seasons

Falcons Trends

  • Kevin Stefanski has faced a team on short rest 16 times as a head coach — he is 10-6 SU/ATS in those games

Trends from Evan Abrams' NFL Betting Primer


49ers vs Falcons Weather

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