Steelers vs. 49ers Odds, Picks & More

Steelers at 49ers Betting Odds

• Odds: 49ers -6.5
• Total: 44.5
• Time: 4:25 p.m. ET
• TV Channel: CBS

Odds above as of Sunday morning and via PointsBet, where Action Network users can exclusively bet every NFL spread this season at reduced juice (-105).

Sean Koerner compares his projected spread and total to the market to identify any potential value, while our staff reveals how they're betting this game.

Sean Koerner's Projected Steelers-49ers Odds

• Projected Spread: 49ers -7
• Projected Total: 45.5

This is a fascinating week from a handicapping perspective as we have multiple future Hall of Fame quarterbacks either out with injury or benched. Ben Roethlisberger is the only one who has suffered a season-ending injury, so it’ll be rookie quarterback Mason Rudolph’s team in Pittsburgh.

It’s a huge loss for the Steelers, whose power rating has taken a big hit.

On the other side of the ball we have a 2-0 49ers team that I still think have one of the most underrated coaches in the NFL in Kyle Shanahan. He’s almost always being dealt a bad hand, yet seems to make the most of it.

The Niners’ luck is starting to turn for the best as they get to face the Steelers for Rudolph’s first start and should absolutely be favored by 6.5 points, which is where the market has settled.  — Sean Koerner

Expert Pick

Mike Randle: 49ers -6.5

This is not an easy way for Rudolph to get his feet wet as an NFL starter.

The Oklahoma State product will face a San Francisco defense that has allowed 34 points and tallied seven sacks in its first two games. The Niners rush defense, which ranks 7th in DVOA, should have the edge over Pittsburgh's suspect ground game, especially if Conners can't go.

Establishing the run will be critical to help give Rudolph some breathing room, but that is easier said than done.

Garoppolo should be able to take advantage of the Pittsburgh secondary which ranks 30th in Football Outsiders' pass defense DVOA.

The Steelers have a chance to pull the upset. They just need Rudolph to play well, running back James Conners' knee to hold up and their secondary to slow down Kyle Shanahan's offense.

That’s too many question marks and leads me to an investment on the Niners at -6.5.