The St. Louis Cardinals host the Baltimore Orioles on August 25, 2026. First pitch from Busch Stadium is scheduled for 7:45 p.m. ET. The game will be broadcast on MASN.
The Cardinals are favored by -132 on the moneyline and by -1.5 on the run line. The Orioles are +112 on the moneyline and +1.5 on the run line. The total is set at 8.5 runs.
Find my MLB picks and Orioles vs Cardinals prediction below, as well as probable pitchers, weather report, and more.
Orioles vs Cardinals Prediction
- Orioles vs Cardinals Pick: Orioles ML (+112)
My Orioles vs Cardinals best bet is on Baltimore to win outright. Make sure to find the best odds by checking our live MLB odds page.
Orioles vs Cardinals Odds
| Orioles Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -192 | 8.5 -122o / -100u | +112 |
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +158 | 8.5 -122o / -100u | -132 |
- Orioles vs Cardinals moneyline: Orioles +112, Cardinals -132
- Orioles vs Cardinals over/under: 8.5 (-122o / -100u)
- Orioles vs Cardinals spread: Orioles +1.5 (-192), Cardinals -1.5 (+158)
Orioles vs Cardinals Probable Pitchers
| Chris Bassitt (RHP, BAL) | Stat | Matthew Liberatore (LHP, STL) |
|---|---|---|
| 4-4 | W-L | 5-11 |
| 0.5 | fWAR (FanGraphs) | 1.1 |
| 5.08 / 5.10 | ERA / xERA | 5.04 / 4.81 |
| 4.58 / 4.78 | FIP / xFIP | 4.44 / 4.06 |
| 6.5 | K-BB% | 15.0 |
| 46.5 | GB% | 36.5 |
| .342 | BABIP | .332 |
| 96 | Stuff+ | 98 |
| 100 | Location+ | 100 |
Orioles vs Cardinals MLB Betting Preview, Prediction
The Orioles managed a 5-5 record through a very strenuous 10-game stretch that featured seven matchups vs. the Rays and three against the Yankees, keeping their hopes of stealing a playoff spot moderately realistic.
The Cardinals, meanwhile, have played to a 22-28 record since July 1st, as their production has sputtered after a surprisingly strong start to the season.
Though not too many people will be keen to back Chris Bassitt in 2026, the Orioles right-hander is backed by a lineup that has been very hard on lefties of late, and that should fare quite well versus Cardinals SP Matthew Liberatore.
Baltimore holds a 116 wRC+ against left-handed pitching since July 1st and ranks first in MLB with a 41.8% hard-hit rate during that span.
Losing Adley Rutschman certainly lowers the lineup's upside, but part of the Orioles' thinking in looking toward the future and dealing Rutschman was the belief that Samuel Basallo is a legitimate offensive talent.
Basallo is now back in the lineup following a lengthy absence, giving Baltimore another potential source of production.
Through a hefty sample of 125 innings, Liberatore has struggled to an ERA of 5.04 with a WHIP of 1.44, and he's been hard-hit 41.7% of the time while walking 8.1% of batters faced.
The Cardinals have hit to a wRC+ of 92 versus right-handed pitching since June 1st, slugging just .371 while ranking 19th in expected weighted on-base average in that span.
Without overselling Bassitt, he's still managed to limit hard contact fairly effectively with his deep arsenal of pitch mixes and shapes, as he has a barrel rate of just 4.4% and has been hard-hit just 35.8% of the time.
His stuff is far from overpowering, and things can go south in a hurry when he's not commanding his curveball, but that's a livable concern with the Orioles priced as underdogs versus Liberatore and a stale offense.
Pick: Orioles Moneyline (+112, FanDuel | Play to +105)
