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Tigers vs Guardians Prediction, Pick, Odds, for Wednesday, September 24

Tigers vs Guardians Prediction, Pick, Odds, for Wednesday, September 24 article feature image
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Photo by Ken Blaze-Imagn Images. Pictured: Jose Ramirez

The Cleveland Guardians host the Detroit Tigers on September 24, 2025. First pitch from Progressive Field is scheduled for 6:40 p.m. EDT; the game will be broadcast on FDSDET.

After tying yesterday atop the AL Central, the Guardians will look to complete their takeover against the Tigers.

Find my MLB betting preview and Tigers vs Guardians prediction below, as well as probable pitchers, betting trends, injury reports and more.

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My Tigers vs Guardians Prediction

  • Tigers vs Guardians pick: Guardians ML -135

My Tigers vs Guardians best bet is on the Guardians moneyline. Make sure to find the best odds by checking our live MLB odds page.


Tigers vs Guardians Odds

Tigers Logo
Wednesday, Sep 24
6:40 p.m. ET
FDSDET
Guardians Logo
Tigers Odds
SpreadTotalMoneyline
+1.5
-190
7.5
-115o / -105u
+115
Guardians Odds
SpreadTotalMoneyline
-1.5
+160
7.5
-115o / -105u
-135
Odds via bet365. Get up-to-the-minute MLB odds here.
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Tigers vs Guardians Projected Starting Pitchers

RHP Jack Flaherty (DET)StatRHP Tanner Bibee (CLE)
8-14W-L11-11
2.4fWAR (FanGraphs)1.7
4.60 / 4.02ERA / xERA4.34 / 3.64
3.87 / 3.75FIP / xFIP4.41 / 4.20
1.28WHIP1.23
18.6K-BB%14.2
36.4GB%44.3
98Stuff+102
102Location+98

Tigers vs Guardians Preview

The Tigers' incredible downfall continues, and the defeats pile up. They are on a seven-game losing streak, and if they don't snap back now against Cleveland, they will lose what once seemed a secure playoff spot.

The Guardians have done their fair share, of course. They've won nine of their past 10 games, and currently rank 9th in wRC+ in September with a 105 rating.

They will face Jack Flaherty, who has had issues on the road all season long. The Detroit starter holds a 5.20 ERA away from home and has been doing worse in his recent outings, with a 4.71 ERA across his past seven games.

Tanner Bibee will oppose him for Cleveland. He's been great over the past seven outings with a 3.57 ERA, and he does much better at Progressive Field with a 3.35 ERA compared to his 5.17 ERA on the road.

Bibbe is also coming off an excellent start versus the Tigers, with only one run and four hits allowed, plus eight strikeouts, in six innings. Overall, he has given up just seven hits and one run in 13 innings this season versus Detroit, with 16 Ks.

Additionally, the Cleveland bullpen ranks third this season with a 3.50.

This aligns with our Bet Labs recommendation to back the red-hot Guardians today.

MLB Icon
Evan Abrams / Bet Labs – Quiet Confidence System
the team's win percentage is between 50% and 100%
the game is played during the Regular season
the team's previous game margin is between 1 and 7
the team's moneyline in their previous game was between 100 and 171
the closing moneyline is between -235 and -125
the team’s home/away streak is between 2 and 8 games
$5,908
WON
335-164-0
RECORD
67%
WIN%

This system identifies winning teams that are performing steadily but not drawing overwhelming market attention.

It targets regular-season teams with at least a breakeven win rate, coming off a modest but positive result, winning their previous game by between one and seven runs.

Their prior moneyline price indicates they weren’t heavy favorites —just expected to win. When they return as moderate favorites again and have a consistent streak of games either home or away, it suggests controlled momentum rather than volatility.

The setup capitalizes on teams that are undervalued by the public due to their lack of flashy blowouts or extreme winning streaks, offering value where confidence exceeds perception.

Pick: Guardians ML -135 (bet365)


Tigers vs Guardians Betting Trends


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