The Cincinnati Reds host the Milwaukee Brewers on September 4, 2026. First pitch from Great American Ball Park is scheduled for 6:10 p.m. ET. The game will be broadcast on BREW.
The Brewers are favored by -164 on the moneyline and by -1.5 on the run line. The Reds are +136 on the moneyline and +1.5 on the run line. The total is set at 9.5 runs.
Find my MLB picks and Brewers vs Reds prediction below, as well as probable pitchers, weather report, and more.
Brewers vs Reds Prediction
- Brewers vs Reds Pick: Reds ML (+136)
My Brewers vs Reds best bet is on Cincinnati to win outright. Make sure to find the best odds by checking our live MLB odds page.
Brewers vs Reds Odds
| Brewers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 -102 | 9.5 -112o / -108u | -164 |
| Reds Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -118 | 9.5 -112o / -108u | +136 |
- Brewers vs Reds moneyline: Brewers -164, Reds +136
- Brewers vs Reds over/under: 9.5 (-112o / -108u)
- Brewers vs Reds spread: Brewers -1.5 (-102), Reds +1.5 (-118)
Brewers vs Reds Probable Pitchers
| Shane Drohan (LHP, MIL) | Stat | Rhett Lowder (RHP, CIN) |
|---|---|---|
| 7-5 | W-L | 6-8 |
| 2.0 | fWAR (FanGraphs) | 1.2 |
| 3.75 / 3.60 | ERA / xERA | 5.14 / 5.12 |
| 3.42 / 3.91 | FIP / xFIP | 4.64 / 4.72 |
| 15.7 | K-BB% | 9.0 |
| 40.3 | GB% | 40.6 |
| .316 | BABIP | .299 |
| 99 | Stuff+ | 87 |
| 100 | Location+ | 104 |
Brewers vs Reds MLB Betting Preview
Milwaukee Brewers Betting Preview
Brewers starter Shane Drohan has better results on the road, while allowing fewer hits and home runs, but he induces fewer strikeouts and grants more walks.
He pitched Cincinnati's tough home park on June 24 and was pulled after 4 1/3 innings because he allowed eight batters to reach base.
This outing may not be as kind as that zero-ER start. Drohan was an incredible SP for his first two months of starts, but he has slid lately. His 4.84 ERA in August is backed by a 4.70 xERA, 4.98 FIP, and 4.98 xFIP.
Despite quality outings in his past two starts, he was used in relief just prior and has not pitched more than 5 1/3 IP since July 31.
Cincinnati Reds Betting Preview
On the opposing mound, Reds starter Rhett Lowder has been converted from starter to reliever and back to starter. He has pitched at least five innings in each of his past seven starts, while throwing at least six innings in four of his past six starts.
Lowder's season-long 5.14 ERA is gaudy. However, he has a league-average 4.11 ERA in the aforementioned past six starts, with average peripherals. He is not a special SP, but he has a 3.35 ERA at home compared to an egregious 6.79 on the road.
Lowder has allowed the same home run total at home and on the road (8), but earns more strikeouts and allows fewer walks in Great American Ballpark, while creating much more soft contact. He will need to do so against a Brewers offense tied for first against RHP (111 wRC+).
Brewers vs Reds Pick, Betting Analysis
There is a 279-run gap between the Brewers and Reds, yet we are taking the team with a -108 differential to win today.
The Reds have won five of their past seven games and have the seventh-best offense in the past two weeks (111 wRC+). While they face the second-best offense in this span (124 wRC+), Cincinnati should take the opening game of this series.
The Brewers bullpen advantage is significant, but they have also pitched much more in the past three days than the Reds' relievers. This moneyline is appetizing if Lowder can continue to provide his usual length for Cincinnati.
Pick: Reds ML (+136, DraftKings)
