MLB Best Bets Wednesday Evening | Odds, Picks for Marlins vs. Rockies & More

MLB Best Bets Wednesday Evening | Odds, Picks for Marlins vs. Rockies & More article feature image

Jasen Vinlove/Miami Marlins/Getty Images. Pictured: Sandy Alcantara (Marlins)

  • After an afternoon slate featuring five games, our staff's attention turns to the evening matchups.
  • Three best bets are featured below, including a player prop for the Marlins vs. Rockies matchup.
  • Read below and formulate your MLB evening betting card now.

There are five day games on Wednesday, but that doesn't mean we're ignoring the value across the night slate.

In fact, our staff has three best bets, including one in the Marlins vs. Rockies game.

Read below for the best MLB odds, best bets and expert picks for Wednesday evening.

Wednesday Evening MLB Best Bets

The team logos in the table below represent each of the matchups that our MLB betting staff is targeting from today's slate of games. Click the team logos for one the matchups below to navigate to a specific bet discussed in this article.

7:05 p.m. ET
Orioles TT Over 3.5 (-125)
7:05 p.m. ET
Nationals +130
8:40 p.m. ET
Sandy Alcantara Over 5.5 Strikeouts (+114)
Specific bet recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game.

Orioles vs. Yankees

Wednesday, May 24
7:05 p.m. ET
Orioles TT Over 3.5 (-125)

By D.J. James

Nestor Cortes Jr. has been a bit unlucky — with a 5.21 ERA against a 3.79 xERA — but he's still not performing nearly as well as he did a season ago. He also owns a 5.87 ERA in May.

The Baltimore Orioles will be his opponent on Wednesday. Tyler Wells, who's pitching for the O's, is on a similar plane as Cortes — with a 3.85 xERA — so there's really not much of a difference with the starting pitching.

The Baltimore lineup has been solid, and bettors should be aware. Against left-handers in May, the Orioles own a 20.4% strikeout rate, a 12.6% walk rate, a .797 OPS and a 123 wRC+.

All of these numbers are stellar, and enough to take advantage of the slumping Cortes.

The Orioles also have seven hitters with a xwOBA over .340 off of southpaws this season.

Finally, New York’s bullpen has its weak spots, especially if the Orioles tee off against Cortes. The Yankees have four arms below a 4.00 xFIP in May, but the middle relief options are questionable.

Baltimore will surely force a few bad arms into the game and hit them hard.

With almost zero weak spots in the batting order, Baltimore is poised for a big offensive game.

Take the Orioles' team total at 3.5 (-125), and play it to 4.5 (-110). This number is far too low for a good hitting team.

Pick: Orioles Team Total Over 3.5 (-125)

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Padres vs. Nationals

Wednesday, May 24
7:05 p.m. ET
Nationals +130

By BJ Cunningham

Given his horrific numbers in Triple-A last season, Ryan Weathers has pitched much better than expected. Weathers has a 3.99 xERA in a little over 20 innings pitched, but some of his other metrics are concerning.

Weathers only has a Stuff+ rating of 89, which is the lowest in the Padres' rotation. He does have a Location+ rating of 101 — bringing his Pitching+ rating up to 95 — but that's still considered below average by MLB standards.

He has a three-pitch mix of fastball, changeup and sweeper. All three pitches have been effective this season in a small sample size.

Despite being in last place in the NL East, the Washington Nationals are one of the best offenses against left-handed pitching. The Nats have a .351 wOBA and 120 wRC+ against lefties this season, which is top-five in baseball.

They also have a +4.9 run value against the left-handed version of Weathers' three pitches (fastball, changeup and sweeper).

Trevor Williams has been bad so far this season, with an xERA over five. He mainly comes at hitters with a fastball/sinker combination that he's gotten away with a tad bit of luck on, as the xwOBA on both pitches is a little higher than the wOBA allowed.

Williams, though, will have a decent matchup against this Padres' lineup.

Despite having maybe the most talent of anyone offensively in baseball, the Padres are bad against fastballs and sinkers. For the season, San Diego has a -8.0 run value and only a .251 xBA against the right-handed version of those two pitches.

I only have the Padres projected at -103, so I like the value on the Nationals at +130

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Marlins vs. Rockies

Wednesday, May 24
8:40 p.m. ET
Sandy Alcantara Over 5.5 Strikeouts (+114)

By Nick Shlain

One of my favorite bets for Wednesday’s slate is Marlins ace pitcher Sandy Alcantara to go over 5.5 strikeouts against the Colorado Rockies at +114 on FanDuel.

Alcantara has a 22% strikeout percentage on the season.

The Rockies don’t strike out a ton, as their projected lineup has combined for just a 21% strikeout percentage against right-handed pitching this season.

Still, the Rockies' projected lineup has mostly left-handed hitters, and that should play to Alcantara’s advantage here.

Alcantara has a significant split when it comes to strikeouts this year. Against left-handed hitters, he has a 25% strikeout percentage compared to just a 19% strikeout percentage against right-handed hitters.

This makes sense, as Alcantara’s best pitch is his changeup, which can be devastating against left-handed batters.

Alcantara has gone over this number quite a bit recently, as he’s had at least six strikeouts in four of his last six starts.

Even in the thin air at Coors Field, I like Alcantara to go over his strikeout total once again here.

Pick: Sandy Alcantara Over 5.5 Strikeouts (+114)

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