The Philadelphia 76ers (0-1) and Boston Celtics (1-0) will square off in Game 2 in the first round of the NBA Playoffs tonight. Tipoff is set for 7:00 p.m. ET from TD Garden in Boston, Massachusetts. The game will stream live on Peacock.
The Celtics are 14.5-point favorites over the Sixers on the spread (Celtics -14.5), with the over/under set at 216.5 total points. Boston is a -850 favorite to win outright on the moneyline, while Philadelphia is +575 to pull off the upset.
Let's get into my 76ers vs. Celtics predictions and NBA picks for Game 2 on Tuesday, April 21.
- 76ers vs Celtics pick: Celtics -14.5 (-110)
My Celtics vs. 76ers Game 2 best bet is on Boston to cover the spread (-14.5). Make sure to find the best odds by checking our live NBA odds page.
76ers vs Celtics Odds for Game 2
| 76ers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+14.5 -110 | 216.5 -110o / -110u | +575 |
| Celtics Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-14.5 -110 | 216.5 -110o / -110u | -850 |
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76ers vs Celtics NBA Playoffs Game 2 Preview
Philadelphia 76ers Betting Preview
The Sixers looked entirely unprepared for playoff basketball in the first game of this series. That could lead to a bounce-back performance — but, Philadelphia's problem was their lack of preparation and mental focus. I don’t know if they can turn that around in 48 hours.
I make the spread for this game Celtics -15 after some adjustments. My model originally made it within the number. So, I trust Boston, what could possibly go wrong?
The Celtics notoriously have a habit of screwing around and losing one game per series. It happens in almost every single series, and it's happened under multiple coaches.
The Sixers’ wings had a really bad shooting performance in Game 1. That should improve, but the confidence and execution that Boston had won’t be affected.
Boston Celtics Betting Preview
The depth of the Celtics is a huge factor.
Philadelphia is tossing out guys like Justin Edwards and Dominick Barlow — and the Celtics’ young guys are just much more polished.
It’s not all pointing in Boston’s direction, though. The Celtics are 1-3-1 ATS under Joe Mazzulla in Game 2 after winning and covering in Game 1.
76ers vs Celtics Pick, Betting Analysis
Celtics -14.5
We thought the Nuggets had control in their first round series against the Wolves; Denver lost. We thought the Knicks had complete control over the Hawks; New York lost. We thought the Cavaliers had complete control over the Raptors; and they did, in fact, and won Game 2 easily.
However, the Sixers are just not on the same level as those teams, as evidenced by their play-in status.
When Joel Embiid gets back, maybe there will be value on the Sixers — but until then, I’ll dare them to hang within the number against a Boston team that, for once, does not seem to be in a mood to screw around.
Quentin Grimes Over 4.5 Rebounds & Assists
Grimes has gone over this line in seven of his last 10 games — and I’m expecting more minutes from him because he’s got more seasoning and can handle the second unit.
Payton Pritchard Over 16.5 Points & Rebounds
Pritchard had a quiet Game 1, but rarely has back-to-back bad games. He's gone over this line in eight of his 10 outings.

76ers vs Celtics Best Bets for Game 2
- Celtics -14.5 (-110)
- Quentin Grimes Over 4.5 Rebounds & Assists (-130)
- Payton Pritchard Over 16.5 Points & Rebounds (-120)


















