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Northwestern vs. USC Odds & Betting Predictions - November 8, 2025

Northwestern at USC

2:00 am • FOX

Northwestern Wildcats

6-1
17
17 - 38

USC Trojans

6-1
38

Northwestern at USC Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Northwestern
6-1
+16.5
+14.5-112
o54.5-108
+472
USC
6-1
u51.5
-14.5-108
u54.5-111
-662
location pinSaturday 2:00 a.m.
November 08, 2025
Los Angeles Memorial ColiseumLos Angeles
Northwestern vs. USC Expert Picks
Collin Wilson
Collin Wilson
Last 30d: 82-73-2 (+0.8u)
USC -14-112
1u
Doug Ziefel
Doug Ziefel
Last 30d: 393-392-9 (+31.9u)
G.Wilde o3.5 Recs-125
0.5u
Duck
Duck
Last 30d: 100-78-2 (+7.3u)
NW +14.5-105
1.05u
Picks Office
Picks Office
Last 30d: 0-0-0 (+0.0u)
NW +14.5-110
1u
X: PicksOffice
Sandy Plashkes
Sandy Plashkes
Last 30d: 106-108-4 (+15.3u)
Over 51-110
1u
Dan Gaspar
Dan Gaspar
Last 30d: 37-33-3 (-0.4u)
C.Komolafe o72.5 Rush Yds-114
1u
💰🦡 Jake
💰🦡 Jake
Last 30d: 94-109-1 (+14.5u)
Under 26.5 (1H)-105
1.58u
John Feltman
John Feltman
Last 30d: 95-58-1 (+20.0u)
USC o16.5 Team Total (1H)-125
3u
USC o33.5 Team Total-125
3u
Lines at Lunch
Lines at Lunch
Last 30d: 0-0-0 (+0.0u)
NW +17-130
1.3u
Over 51-110
1u
Babs .
Babs .
Last 30d: 45-36-1 (+2.2u)
Over 50.5-118
0.85u
NW +17-130
1u

Northwestern vs. USC Previews & Analysis

  • Northwestern vs. USC: Trojans Will Roll article feature image

    Northwestern vs. USC: Trojans Will Roll

    John Feltman•
    Nov 8, 2025 UTC
  • Our +156 SGP For Northwestern-USC article feature image

    Our +156 SGP For Northwestern-USC

    Dead President Picks•
    Nov 7, 2025 UTC
  • How We're Betting Friday's NCAAF Games article feature image

    How We're Betting Friday's NCAAF Games

    Action Network Staff•
    Nov 7, 2025 UTC
  • +272 Night Cap Contrarian Parlay (9 ET) article feature image

    +272 Night Cap Contrarian Parlay (9 ET)

    Alex Kolodziej•
    Nov 7, 2025 UTC
See more NCAAF Coverage Right Arrow

Prop Odds Comparison

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Line Movement Tracker

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Northwestern vs. USC Public Betting Percentages

Away Logo

Northwestern

Public

Home Logo

USC

48%

Bets%

52%

Money%

NCAAF Public Betting Right Arrow

Betting Trends

  • USC are 4-1 in their last 5 games.
  • USC are 2-3 in their last 5 games against the spread
  • USC are 1-1 in their road games against the spread
  • The totals have gone OVER in 2 of USC' last 5 games
  • The totals have gone OVER in 3 of USC' 5 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
USC		2-51-41-11-30-1
Northwestern		5-24-11-13-22-0

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
USC		4-33-21-12-21-0
Northwestern		4-2-13-1-11-13-21-0-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
USC		6-1N/AN/A4-00-1
Northwestern		6-1N/AN/A5-01-1

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Nov 1st@NEBW 21-17-4.5 LU 59.5USC -200
Oct 18th@NDL 24-34+10.5 WU 60.5ND +300
Oct 11thMICHW 31-13-3 WU 58.5USC -160
Sep 27th@ILLL 32-34-6.5 LO 62ILL -250
Sep 21stMSUW 45-31-18.5 LO 55.5USC -950
Team Stats

Total

280
Total Yards
482
55
Total Plays
64
5.090909090909091
Yards Per Play
7.53125

Passing

150
YDS
309
20/30
Comps/Atts
25/34
5
YPA
9.088235294117647
1/0
TDs/INTs
2/1
2/15
Sacks/Yards
1/9

Rushing

130
Rush Yards
173
25
Attempts
30
5.2
YPC
5.766666666666667
1
TDs
3

Turnovers

2
Fumbles Lost
0
0
Interceptions
1

Efficiency

3/3 100%
Redzone
6/6 100%
4/12 0%
3rd Down
6/11 0%
1/2 0%
4th Down
2/2 0%

First Downs

13
Total
24
4
Pass
14
8
Rush
8
1
Penalty
2

Misc

2/26
Penalties/Yards
4/30

Northwestern vs. USC Odds Comparison

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Northwestern at USC Team Totals

MatchupOverUnder
Northwestern
6-1
N/A
N/A
USC
6-1
N/A
N/A